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논문 기본 정보

자료유형
학술저널
저자정보
이예원 (서울대학교병원 흉부외과) 김수현 (서울대학교 의과대학 흉부외과) 황호영 (서울대학교병원 흉부외과) 손석호 (서울대학교병원 흉부외과) 최재웅 (서울대학교) 김경환 (서울대학교병원)
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care 제36권 제3호
발행연도
2021.8
수록면
242 - 248 (7page)
DOI
10.4266/acc.2021.00094

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Background: Acute kidney injury (AKI) is a major complication after cardiac surgery and sig nificantly affects postoperative mortality and morbidity. This study was conducted to evalu ate the association between target pump flow to achieve adequate oxygen delivery (DO2) and postoperative renal function after aortic valve replacement. Methods: From January 2017 to May 2020, 281 patients (male:female, 160:121; mean age, 68±11 years) who underwent aortic valve replacement were retrospectively reviewed. Target pump flow was calculated based on DO2 level of 280 mL/min/m2 . The primary endpoint was postoperative renal dysfunction, defined as the ratio of postoperative peak creatinine level to preoperative value. The ratio of the lowest actual pump flow to the ideal target pump flow, other hemodynamic variables related with cardiopulmonary bypass, intraoperative transfu sion, and preoperative characteristics were analyzed to identify factors associated with the primary endpoint using a multivariable linear regression model. Results: Preoperative and peak postoperative creatinine levels were 0.94±0.33 mg/dl and 1.15±0.56 mg/dl, respectively (ratio, 1.22±0.33). The ideal target pump flow was 4.70±0.59 L/min, whereas the lowest actual pump flow was 3.77±0.47 L/min (ratio, 0.81±0.13). The multivariable model showed that the ratio of the lowest pump flow to target pump flow (β±standard error, ?0.405±0.162, P=0.013), as well as sex, stroke history, emergency opera tion, and transfusion of red blood cells were associated with the primary endpoint. Conclusions: Low actual nadir pump flow compared to the ideal target pump flow based on DO2 is associated with the risk of AKI after aortic valve replacement.

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