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학술저널
저자정보
남경훈 (아주대병원) 강형구 (인제대학교부속일산백병원) 이성순 (인제대일산백병원) 박소희 (인제대일산백병원) 강성욱 (강동경희대병원) 황재준 (강동경희대병원) 박소영 (이화의대서울병원) 김원영 (서울아산병원) 서희정 (서울아산병원) 김은영 (서울아산병원) 서가진 (서울아산병원) 고윤석 (울산의대 서울아산병원) 홍상범 (서울아산병원) 허진원 (서울아산병원) 임채만 (서울아산병원)
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care 제36권 제3호
발행연도
2021.8
수록면
249 - 255 (7page)
DOI
10.4266/acc.2020.01102

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Background: Evidence for using high-flow nasal cannula (HFNC) in hypercapnia is still limit ed. Most of the clinical studies had been conducted retrospectively, and there had been con flicting reports for the effects of HFNC on hypercapnia correction in prospective studies. Therefore, more evidence is needed to understand the effect of the HFNC in hypercapnia. Methods: We conducted a multicenter prospective observational study after applying HFNC to 45 hospitalized subjects who had moderate hypercapnia (arterial partial pressure of carbon dioxide [PaCO2], 43?70 mm Hg) without severe respiratory acidosis (pH <7.30). The primary outcome was a change in PaCO2 level in the first 24 hours of HFNC use. The secondary out comes were changes in other parameters of arterial blood gas analysis, changes in respiration rates, and clinical outcomes. Results: There was a significant decrease in PaCO2 in the first hour of HFNC application (-3.80 mm Hg; 95% confidence interval, -6.35 to -1.24; P<0.001). Reduction of PaCO2 was more prominent in subjects who did not have underlying obstructive lung disease. There was a cor rection in pH, but no significant changes in respiratory rate, bicarbonate, and arterial partial pressure of oxygen/fraction of inspired oxygen ratio. Mechanical ventilation was not required for 93.3% (42/45) of our study population. Conclusions: We suggest that HFNC could be a safe alternative for oxygen delivery in hyper capnia patients who do not need immediate mechanical ventilation. With HFNC oxygenation, correction of hypercapnia could be expected, especially in patients who do not have obstruc tive lung diseases

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