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자료유형
학술저널
저자정보
Alireza Fatemi (Shahid Beheshti University of Medical Sciences Tehran) Seyed Hossein Ardehali (Shohadaye Tajrish Hospital Shahid Beheshti University of Medical Sciences Tehran Iran) Ghazaleh Eslamian (Shahid Beheshti University of Medical Sciences) Morvarid Noormohammadi (Shahid Beheshti University of Medical Sciences) Shirin Malek (California State University)
저널정보
대한중환자의학회 Acute and Critical Care Acute and Critical Care 제36권 제4호
발행연도
2021.11
수록면
300 - 307 (8page)
DOI
10.4266/acc.2021.00605

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Background As the coronavirus disease 2019 (COVID-19) pandemic continues to escalate, it is important to identify the prognostic factors related to increased mortality and disease severity. To assess the possible associations of vitamin D level with disease severity and survival, we studied 248 hospitalized COVID-19 patients in a single center in a prospective observational study from October 2020 to May 2021 in Tehran, Iran. Methods Patients who had a record of their 25-hydroxyvitamin D level measured in the previous year before testing positive with COVID-19 were included. Serum 25-hydroxyvitamin D level was measured upon admission in COVID-19 patients. The associations between clinical outcomes of patients and 25-hydroxyvitamin D level were assessed by adjusting for potential confounders and estimating a multivariate logistic regression model. Results The median (interquartile range) age of patients was 60 years (44?74 years), and 53% were male. The median serum 25-hydroxyvitamin D level prior to admission decreased with increasing COVID-19 severity (P=0.009). Similar findings were obtained when comparing median serum 25-hydroxyvitamin D on admission between moderate and severe patients (P=0.014). A univariate logistic regression model showed that vitamin D deficiency prior to COVID-19 was associated with a significant increase in the odds of mortality (odds ratio, 2.01; P=0.041). The multivariate Cox model showed that vitamin D deficiency on admission was associated with a significant increase in risk for mortality (hazard ratio, 2.35; P=0.019). Conclusions: Based on our results, it is likely that deficient vitamin D status is associated with increased mortality in COVID-19 patients. Thus, evaluating vitamin D level in COVID-19 patients is warranted.

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