지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
The present study is designed to investigate the hypolipidemic effect of the hot-water extract from the leaves of Dendropanax morbifera L. (DMWE) in hyperlipidemic rats. Thirty male 5-week-old rats were grouped as follows: Normal control (NC) given distilled water; hyperlipidemic control (HC) administered with distilled water; drug treatment (DT) orally administered with atorvastatin (10 mg/kg body weight (BW)); DMWE-treated groups (DM-50, DM-100 and DM-200) treated with DMWE 50, 100 and 200 mg/kg BW, respectively. All groups (except for NC) were fed a high-fat diet during the experiment. After 4 weeks of administration, the BW of all groups treated with DMWEs significantly increased compared to that of HC (p<0.05) and showed no significant difference compared to that of NC. In addition, serum total cholesterol levels in all groups treated with DMWEs were meaningfully decreased, compared to that in HC (p<0.05). In serum triglyceride (TG) and low-density lipoprotein-cholesterol levels, both DM-100 and DM-200 considerably decreased compared to HC (p<0.05), and no significant differences in TG levels were between DM-100 and DM-200.
In high-density lipoprotein-cholesterol levels, DM-200 was statistically different compared to HC, and there were no significant differences between DM-100, DM-200 and DT. Furthermore, aspartate transaminase and alanine aminotransferase concentrations of DM-100 and DM-200 were significantly decreased compared to those of HC (p<0.05). From results portrayed above, DMWE at the concentration of 100 mg/kg BW has been identified to be effective in the treatment of hyperlipidemic rats.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
안준철 / 2002 / 황칠수액 분비 우수개체 선발 및 방향성 정유성분 조사 / 한국약용작물학회지 10(2):126~131
Al-Otaibia SN / 2020 / Antihyperlipidemic and hepatic antioxidant effects of Leek leaf methanol extract in high fat diet-fed rats / All LIfe 13:373~385
안나영 / 2014 / Streptozotocin에 의해 유도된 당뇨모델동물에서 황칠나무 (Dendropanax morbifera Leveille)의 열수추출물과 에탄올추출물의 당뇨 질환 개선 효능 / Journal of Nutrition and Health 47(6):394~402
Desu B / 2013 / Anti-hyperlipidemic activity of methanolic extract of rhinacanthus nasutus / Int J Res Pharm Chem 3:708~711
Ebaid H / 2019 / Efficacy of a methanolic extract of Adansonia digitata leaf in alleviating hyperglycemia, hyperlipidemia, and oxidative stress of diabetic rats / Biomed Res Int 2019:2835152
Al-Otaibia SN / 2020 / Antihyperlipidemic and hepatic antioxidant effects of Leek leaf methanol extract in high fat diet-fed rats / All LIfe 13:373~385
안나영 / 2014 / Streptozotocin에 의해 유도된 당뇨모델동물에서 황칠나무 (Dendropanax morbifera Leveille)의 열수추출물과 에탄올추출물의 당뇨 질환 개선 효능 / Journal of Nutrition and Health 47(6):394~402
Desu B / 2013 / Anti-hyperlipidemic activity of methanolic extract of rhinacanthus nasutus / Int J Res Pharm Chem 3:708~711
Ebaid H / 2019 / Efficacy of a methanolic extract of Adansonia digitata leaf in alleviating hyperglycemia, hyperlipidemia, and oxidative stress of diabetic rats / Biomed Res Int 2019:2835152
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Streptozotocin으로 유도된 당뇨 랫드에서 황칠나무 잎 열수추출물의 항당뇨 효과
Korean Journal of Veterinary Research(대한수의학회지)
2021 .12
-
Acute oral toxicity of Dendropanax morbiferus H.Lév leaf extracts in ICR mice
예방수의학회지
2023 .03
-
Clinical and Laboratory Characteristics of Childhood Diabetes Mellitus: A Single-Center Study from 2000 to 2013
전남의대학술지
2016 .01
-
Long-term prognosis and clinical characteristics of patients with newly diagnosed diabetes mellitus detected after the first acute myocardial infarction: From the KAMIR-NIH registry
Korean Circulation Journal
2018 .01
-
Subacute oral toxicity of Dendropanax morbiferus H.Lév leaf extracts in Sprague-Dawley rats
예방수의학회지
2023 .03
-
Incidence trends and associated factors of diabetes mellitus in Korean children and adolescents: a retrospective cohort study in Busan and Gyeongnam
Annals of Pediatirc Endocrinology & Metabolism
2015 .01
-
Impact of Severe Hypercholesterolemia on Cardiovascular Risk in Individuals With or Without Diabetes Mellitus
지질·동맥경화학회지
2022 .09
-
Does Diabetes Mellitus Influence Carpal Tunnel Syndrome?
Journal of Clinical Neurology
2017 .07
-
소아청소년 제2형 당뇨병의 진단과 치료
대한의사협회지
2021 .01
-
Genetic aspects of type 1 diabetes
Annals of Pediatirc Endocrinology & Metabolism
2019 .01
-
Prediction of diabetes mellitus after kidney transplantation using patient-specific induced pluripotent stem cells
Kidney Research and Clinical Practice
2024 .03
-
Insulin Fact Sheet in Type 1 and 2 Diabetes Mellitus and Trends of Antidiabetic Medication Use in Insulin Users with Type 2 Diabetes Mellitus: 2002 to 2019
Diabetes and Metabolism Journal
2023 .03
-
Incidence, Predictors, and Clinical Outcomes of New-Onset Diabetes Mellitus after Percutaneous Coronary Intervention with Drug-Eluting Stent
Journal of Korean Medical Science
2017 .01
-
Cognitive dysfunctions in individuals with diabetes mellitus
Journal of Yeungnam Medical Science
2019 .01
-
Concentrations of trace metals in serum: Implications for type 2 diabetes mellitus and gender difference
Environmental Analysis Health and Toxicology
2025 .03
-
The Clinical Characteristics and Outcomes of Patients with Moderate-to-Severe Coronavirus Disease 2019 Infection and Diabetes in Daegu, South Korea
Diabetes and Metabolism Journal
2020 .01
-
Depression and Mortality in People with Type 2 Diabetes Mellitus, 2003 to 2013: A Nationwide Population-Based Cohort Study
Diabetes and Metabolism Journal
2017 .01
-
Influence of Glucose Fluctuation on Peripheral Nerve Damage in Streptozotocin-Induced Diabetic Rats
Diabetes and Metabolism Journal
2022 .01
-
The Risk of Diabetes on Clinical Outcomes in Patients with Coronavirus Disease 2019: A Retrospective Cohort Study
Diabetes and Metabolism Journal
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0