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논문 기본 정보

자료유형
학술저널
저자정보
Bahremand Mostafa (Kermanshah University of Medical Sciences) Zereshki Ehsan (Research Center for Environmental Determinants of Health (RCEDH)) Matin Behzad Karami (Kermanshah University of Medical Sciences) Rezaei Mansour (Kermanshah University of Medical Sciences) Omrani Hamidreza (Kermanshah University of Medical Sciences)
저널정보
대한고혈압학회 Clinical Hypertension Clinical Hypertension 제27권 제4호
발행연도
2021.10
수록면
14 - 23 (10page)
DOI
10.1186/s40885-021-00170-6

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Background: Coronary artery ectasia (CAE) is characterized by the enlargement of a coronary artery to 1.5 times or more than other non-ectasia parts of the vessel. It is important to investigate the association of different factors and CAE because there are controversial results between available studies. We perform this systematic review and metaanalysis to evaluate the effects of hypertension (HTN) on CAE. Methods: To find the potentially relevant records, the electronic databases, including Scopus, PubMed, and Science Direct were searched on 25 July 2019 by two of the authors independently. In the present study, the pooled odds ratio (OR) accompanied by 95 % confidence intervals (CIs) were calculated by a random-effects model. Heterogeneity presented with the I2 index. Subgroup analysis and sensitivity analysis by the Jackknife approach was performed. Results: Forty studies with 3,263 cases and 7,784 controls that investigated the association between HTN and CAE were included. The pooled unadjusted OR of CAE in subjects with HTN in comparison by subjects without HTN was estimated 1.44 (95 % CI, 1.24 to 1.68) with moderate heterogeneity (I2 = 41 %, Cochran’s Q P = 0.004). There was no evidence of publication bias in the analysis of HTN and CAE with Egger’s test (P = 0.171), Begg’s test (P = 0.179). Nine articles reported the adjusted effect of HTN on CAE by 624 cases and 628 controls. The findings indicated the overall adjusted OR was 1.03 (95 % CI, 0.80 to 1.25) with high heterogeneity (I2 = 58.5 %, Cochran’s Q P = 0.013). Conclusions: We found that when the vessel was in normal condition, HTN was not very effective in increasing the chance of CAE and only increased the CAE chance by 3 %. This is an important issue and a warning to people who have multiple risk factors together. More studies need to be performed to further establish these associations by reported adjusted effects.

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