돌발성 난청에서 스테로이드 투여 방법에 따른 치료 결과의 차이

정재호; 김인식; 김동환; 윤형준; 박철원; 이승환

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자료유형: 학술저널

저자정보: 정재호 (한양대학교) 김인식 (한양대학교) 김동환 (한양대학교 의과대학 이비인후과학교실) 윤형준 (한양대학교 의과대학 이비인후-두경부외과학교실) 박철원 (한양대학교) 이승환 (한양대학교)

저널정보: 대한이비인후과학회 부산,울산,경남 지부회 임상이비인후과 임상이비인후과 제28권 제1호

발행연도: 2017.6

수록면: 42 - 48 (7page)

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연구방법

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연구결과

초록· 키워드

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The aims of the study was to compare the treatment outcomes associated with the steroid administration routes in unilateral sudden sensorineural hearing loss. Methods：From January 1998 to December 2014, three hundred and eighteen patients with unilateral sudden sensorineural hearing loss were assessed. Among them, 34 patients received the intravenous dexamethasone (16 mg/day)while the others 284 patients received 1mg/kg prednisolone daily with a subsequently tapered dose. We performed a propensity score matching analysis using previously known prognostic factors including initial hearing level, presence of vertigo and duration of onset of treatment to compare treatment outcome of IV and oral steroid. The hearing recovery between the IV steroid group and propensity score matched oral steroid group was assessed according to the AAO-HNS guideline and Siegel’s criteria. Results：In the comparison between oral and IV steroid group, mean age, the initial hearing level was significantly higher in the oral steroid group than in IV steroid group (p=0.002, p=0.003) After propensity score matching, initial hearing level, age, sex and other clinical parameters were not significantly different between IV steroid and matched oral steroid group. In the treatment outcome, the complete recovery rate in IV steroid and the oral steroid group were 64.7% and 47.1% respectively. Although the recovery rate of the IV steroid group was higher than that of the oral steroid group, statistical significance was not identified. Conclusions：The administration route of systemic steroid did not affect the clinical outcomes of idiopathic sudden sensorineural hearing loss.

#돌발성난청·스테로이드. #Sudden sensorineural hearing lossㆍSteroid.

참고문헌 (22)

참고문헌 신청

Chau JK / 2010 / Systematic review of the evidence for the etiology of adult sudden sensorineural hearing loss / Laryngoscope 120(5):1011~1021

Stokroos R / 1995 / The etiology of idiopathic sudden sensorineural hearing loss. A review of the literature / Acta Oto-Rhino-Laryngologica Belgica 50(1):69~76

Chung JH / 2016 / Clinical significance of arterial stiffness in idiopathic sudden sensorineural hearing loss. / Laryngoscope 126(8):1918~1922

Egli Gallo D / 2013 / Effectiveness of systemic high-dose dexamethasone therapy for idiopathic sudden sensorineural hearing loss / Audiol Neurootol 18(3):161~170

Schreiber BE / 2010 / Sudden sensorineural hearing loss / Lancet 375(9721):1203~1211

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