지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.11
- 수록면
- 473 - 480 (8page)
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초록· 키워드
오류제보하기
Quantitative RNA analyses of autopsy materials to diag-nose the cause and mechanism of death are challenging tasks in the field of forensic molecular pathology. Altera-tions in mRNA profiles can be induced by cellular stress responses during supravital reactions as well as by lethal insults at the time of death. Here, we demonstrate that several gene transcripts encoding heat shock proteins (HSPs), a gene family primarily responsible for cellular stress responses, can be differentially expressed in the occipital region of postmortem human cerebral cortices with regard to the cause of death. HSPA2 mRNA levels were higher in subjects who died due to mechanical as-phyxiation (ASP), compared with those who died by trau-matic injury (TI). By contrast, HSPA7 and A13 gene tran-scripts were much higher in the TI group than in the ASP and sudden cardiac death (SCD) groups. More importantly, relative abundances between such HSP mRNA species exhibit a stronger correlation to, and thus provide more discriminative information on, the death process than does routine normalization to a housekeeping gene. Therefore, the present study proposes alterations in HSP mRNA composition in the occipital lobe as potential forensic biological markers, which may implicate the cause and process of death.
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등록된 정보가 없습니다.
참고문헌 (52)
참고문헌 신청
Aoki, M. / 1993 / Temporal profile of the induction of heat shock protein 70 and heat shock cognate protein 70 mRNAs after transient ischemia in gerbil brain / Brain Res 601:185~192
Bjarnadóttir, S. G. / 2010 / Proteome changes in bovine longissimus thoracis muscle during the first 48 h postmortem: shifts in energy status and myofibrillar stability / J. Agric. Food Chem 58:7408~7414
Brun, A. / 1976 / Distribution of cerebral degeneration in Alzheimer’s disease. A clinico-pathological study / Arch. Psychiatr. Nervenkr 223:15~33
Calabrese, V. / 2006 / Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity / Antioxid. Redox. Signal 8:444~477
Catts, V. S. / 2005 / A microarray study of postmortem mRNA degradation in mouse brain tissue / Brain Res. Mol. Brain Res 138:164~177
Bjarnadóttir, S. G. / 2010 / Proteome changes in bovine longissimus thoracis muscle during the first 48 h postmortem: shifts in energy status and myofibrillar stability / J. Agric. Food Chem 58:7408~7414
Brun, A. / 1976 / Distribution of cerebral degeneration in Alzheimer’s disease. A clinico-pathological study / Arch. Psychiatr. Nervenkr 223:15~33
Calabrese, V. / 2006 / Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity / Antioxid. Redox. Signal 8:444~477
Catts, V. S. / 2005 / A microarray study of postmortem mRNA degradation in mouse brain tissue / Brain Res. Mol. Brain Res 138:164~177
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