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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.10
- 수록면
- 759 - 765 (7page)
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N-myc downstream-regulated gene 2 (NDRG2), which is known to have tumor suppressor functions, is frequently down-regulated in breast cancers and potentially involved in preventing the migration and invasion of malignant tumor cells. In the present study, we examined the inhibitory effects of NDRG2 overexpression, specifically focusing on the role of cyclooxygenase-2 (COX-2) in the migration of breast cancer cells. NDRG2 overexpression in MDA-MB-231 cells inhibited the expression of the COX-2 mRNA and protein, the transcriptional activity of COX-2, and prostaglandin E2 (PGE2) production, which were induced by a treatment with phorbol-12-myristate-13-acetate (PMA). Nuclear transcription factor-κB (NF-κB) signaling attenuated by NDRG2 expression resulted in a decrease in PMA-induced COX-2 expression. Interestingly, the inhibition of COX-2 strongly suppressed PMA-stimulated migration and invasion in MDA-MB-231-NDRG2 cells. Moreover, siRNA-mediated knockdown of NDRG2 in MCF7 cells increased the COX-2 mRNA and protein expression levels and the PMA-induced COX-2 expression levels. Consistent with these results, the migration and invasion of MCF7 cells treated with NDRG2 siRNA were significantly enhanced following treatment with PMA. Taken together, our data show that the inhibition of NF-κB signaling by NDRG2 expression is able to suppress cell migration and invasion through the down-regulation of COX-2 expression.
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참고문헌 (26)
참고문헌 신청
Chen, C. C. / 2013 / Androgen receptor promotes the migration and invasion of upper urinary tract urothelial carcinoma cells through the upregulation of MMP-9 and COX-2 / Oncol. Rep 30:979~985
Deng, Y. / 2003 / N-Myc downstream-regulated gene 2(NDRG2)inhibits glioblastoma cell proliferation / Int. J. Cancer 106:342~347
Flowers, M. / 2009 / t10c12 conjugated linoleic acid suppresses HER2 protein and enhances apoptosis in SKBr3 breast cancer cells: possible role of COX2 / PLoS One 4:e5342
Fosslien, E. / 2000 / Biochemistry of cyclooxygenase(COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia / Crit. Rev. Clin. Lab. Sci 37:431~502
Funakoshi-Tago, M. / 2008 / Celecoxib potently inhibits TNFalpha-induced nuclear translocation and activation of NFkappaB / Biochem. Pharmacol 76:662~671
Deng, Y. / 2003 / N-Myc downstream-regulated gene 2(NDRG2)inhibits glioblastoma cell proliferation / Int. J. Cancer 106:342~347
Flowers, M. / 2009 / t10c12 conjugated linoleic acid suppresses HER2 protein and enhances apoptosis in SKBr3 breast cancer cells: possible role of COX2 / PLoS One 4:e5342
Fosslien, E. / 2000 / Biochemistry of cyclooxygenase(COX)-2 inhibitors and molecular pathology of COX-2 in neoplasia / Crit. Rev. Clin. Lab. Sci 37:431~502
Funakoshi-Tago, M. / 2008 / Celecoxib potently inhibits TNFalpha-induced nuclear translocation and activation of NFkappaB / Biochem. Pharmacol 76:662~671
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