지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 89 - 94 (6page)
- DOI
- 10.14348/molcells.2015.2285
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초록· 키워드
오류제보하기
The shape and activity of mitochondria are tightly regulated by fusion and fission processes that are essential for maintaining normal cellular function. However, little is known about the involvement of mitochondrial dynamics in the development of the immune system. In this study, we demonstrate that mitochondrial dynamics play a role in the differentiation and migration of immature dendritic cells (imDCs). We show that mitochondrial elongation is induced during GM-CSF-stimulated differentiation of bone marrow progenitors to imDCs accompanied by upregulation of mitochondrial fusion proteins. These processes precede the changes in mitochondrial morphology and connectivity that occur during differentiation. Mfn2 and OPA1, but not Mfn1, are transcriptionally upregulated during differentiation; however, knockdown of Mfn2 and OPA1 does not induce any change in expression of CD11c, CDC80, or CD86. Notably, knockdown of Mfn2 or OPA1 by siRNA in imDCs significantly reduces CCR7 expression and CCL19-mediated migration.
These results suggest that the mitochondrial fusion- related proteins Mfn2 and OPA1 are upregulated during bone marrow progenitor differentiation and promote the migration of imDCs by regulating the expression of CCR7.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Aihara, T. / 2009 / A novel potential role for gametogenetin-binding protein 1(GGNBP1)in mitochondrial morphogenesis during spermatogenesis in mice / Biol. Reprod 80:762~770
Bach, D. / 2003 / Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity / J. Biol. Chem 278:17190~17197
Banchereau, J. / 1998 / Dendritic cells and the control of immunity / Nature 392:245~252
Barbieri, E. / 2011 / Morphofunctional and biochemical approaches for studying mitochondrial changes during myoblasts differentiation / J. Aging Res 2011:845379
Bustos, R. I. / 2013 / Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of MFN2 and OPA1 in erythropoietic cells / Biochem. Biophys. Res. Commun 437:426~432
Bach, D. / 2003 / Mitofusin-2 determines mitochondrial network architecture and mitochondrial metabolism. A novel regulatory mechanism altered in obesity / J. Biol. Chem 278:17190~17197
Banchereau, J. / 1998 / Dendritic cells and the control of immunity / Nature 392:245~252
Barbieri, E. / 2011 / Morphofunctional and biochemical approaches for studying mitochondrial changes during myoblasts differentiation / J. Aging Res 2011:845379
Bustos, R. I. / 2013 / Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of MFN2 and OPA1 in erythropoietic cells / Biochem. Biophys. Res. Commun 437:426~432
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