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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 112 - 121 (10page)
- DOI
- 10.14348/molcells.2015.2101
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초록· 키워드
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Ectopic expression of 14-3-3ζ has been found in various malignancies, including lung cancer, liver cancer, head and neck squamous cell carcinoma (HNSCC), and so on.
However, the effect of 14-3-3ζ in the regulation of interactions between tumor cells and the immune system has not been previously reported. In this study, we aimed to investigate whether and how 14-3-3ζ is implicated in tumor inflammation modulation and immune recognition evasion.
In oral squamous cell carcinoma (OSCC) cell lines and cancer tissues, we found that 14-3-3ζ is overexpressed. In OSCC cells, 14-3-3ζ knockdown resulted in the up-regulated expression of inflammatory cytokines. In contrast, 14-3-3ζ introduction attenuated cytokine expression in human normal keratinocytes and fibroblasts stimulated with interferon- ζ (IFN-ζ) and lipopolysaccharide (LPS). Furthermore, supernatants from 14-3-3ζ knockdown OSCC cells dramatically altered the response of peritoneal macrophages, dendritic cells and tumor-specific T cells. Interestingly, Stat3 was found to directly interact with 14-3-3ζ and its disruption relieved the inhibition induced by 14-3-3ζ in tumor inflammation. Taken together, our studies provide evidence that 14-3-3ζ may regulate tumor inflammation and immune response through Stat3 signaling in OSCC.
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등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
Aitken, A. / 1996 / 14-3-3 and its possible role in co-ordinating multiple signalling pathways / Trends Cell Biol 6:341~347
Bettendorf, O. / 2004 / Prognostic and predictive factors in oral squamous cell cancer : important tools for planning individual therapy? / Oral Oncol 40:110~119
Bromberg, J. F. / 1999 / Stat3 as an oncogene / Cell 98:295~303
Butt, A. Q. / 2012 / 14-3-3epsilon and 14-3-3sigma inhibit Toll-like receptor(TLR)-mediated proinflammatory cytokine induction / J. Biol. Chem 287:38665~38679
Choi, J. E. / 2011 / Silencing of 14-3-3zeta over-expression in hepatocellular carcinoma inhibits tumor growth and enhances chemosensitivity to cis-diammined dichloridoplatium / Cancer Lett 303:99~107
Bettendorf, O. / 2004 / Prognostic and predictive factors in oral squamous cell cancer : important tools for planning individual therapy? / Oral Oncol 40:110~119
Bromberg, J. F. / 1999 / Stat3 as an oncogene / Cell 98:295~303
Butt, A. Q. / 2012 / 14-3-3epsilon and 14-3-3sigma inhibit Toll-like receptor(TLR)-mediated proinflammatory cytokine induction / J. Biol. Chem 287:38665~38679
Choi, J. E. / 2011 / Silencing of 14-3-3zeta over-expression in hepatocellular carcinoma inhibits tumor growth and enhances chemosensitivity to cis-diammined dichloridoplatium / Cancer Lett 303:99~107
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