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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.2
- 수록면
- 156 - 162 (7page)
- DOI
- 10.14348/molcells.2015.2259
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초록· 키워드
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Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3’ untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.
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참고문헌 (33)
참고문헌 신청
Al-Ahmadi, W. / 2013 / miR-29a inhibition normalizes HuR over-expression and aberrant AU-rich mRNA stability in invasive cancer / J. Pathol 230:28~38
Al-Souhibani, N. / 2010 / The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes / Oncogene 29:4205~4215
Andreasen, P. A. / 2000 / The plasminogen activation system in tumor growth, invasion, and metastasis / Cell Mol. Life Sci 57:25~40
Audic, Y. / 2004 / Post-transcriptional regulation in cancer / Biol. Cell 96:479~498
Bakheet, T. / 2001 / ARED : human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins / Nucleic Acids Res 29:246~254
Al-Souhibani, N. / 2010 / The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes / Oncogene 29:4205~4215
Andreasen, P. A. / 2000 / The plasminogen activation system in tumor growth, invasion, and metastasis / Cell Mol. Life Sci 57:25~40
Audic, Y. / 2004 / Post-transcriptional regulation in cancer / Biol. Cell 96:479~498
Bakheet, T. / 2001 / ARED : human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins / Nucleic Acids Res 29:246~254
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