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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.4
- 수록면
- 336 - 342 (7page)
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Propyl gallate (PG) used as an additive in various foods has antioxidant and anti-inflammatory effects. Although the functional roles of PG in various cell types are well characterized, it is unknown whether PG has effect on stem cell differentiation. In this study, we demonstrated that PG could inhibit adipogenic differentiation in human adipose tissue-derived mesenchymal stem cells (hAMSCs) by decreasing the accumulation of intracellular lipid droplets.
In addition, PG significantly reduced the expression of adipocyte-specific markers including peroxisome proliferator- activated receptor-γ (PPAR-γ), CCAAT enhancer binding protein-α (C/EBP-α), lipoprotein lipase (LPL), and adipocyte fatty acid-binding protein 2 (aP2). PG inhibited adipogenesis in hAMSCs through extracellular regulated kinase (ERK) pathway. Decreased adipogenesis following PG treatment was recovered in response to ERK blocking.
Taken together, these results suggest a novel effect of PG on adipocyte differentiation in hAMSCs, supporting a negative role of ERK1/2 pathway in adipogenic differentiation.
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참고문헌 (41)
참고문헌 신청
Abdo, K. M. / 1986 / No evidence of carcinogenicity of D-mannitol and propyl gallate in F344 rats or B6C3F1 mice / Food Chem. Toxicol 24:1091~1097
Bianco, P. / 2008 / Mesenchymal stem cells : revisiting history, concepts, and assays / Cell Stem Cell 2:313~319
Hee-Shin Bin / 2012 / Myricetin Inhibits Adipogenesis in Human Adipose Tissue-derived Mesenchymal Stem Cells / Food Science and Biotechnology 21(5):1391~1396
Camp, H. S. / 1997 / Regulation of peroxisome proliferator-activated receptor gamma activity by mitogenactivated protein kinase / J. Biol. Chem 272:10811~10816
Chen, F. H. / 2006 / Technology Insight : adult stem cells in cartilage regeneration and tissue engineering / Nat. Clin. Pract. Rheumatol 2:373~382
Bianco, P. / 2008 / Mesenchymal stem cells : revisiting history, concepts, and assays / Cell Stem Cell 2:313~319
Hee-Shin Bin / 2012 / Myricetin Inhibits Adipogenesis in Human Adipose Tissue-derived Mesenchymal Stem Cells / Food Science and Biotechnology 21(5):1391~1396
Camp, H. S. / 1997 / Regulation of peroxisome proliferator-activated receptor gamma activity by mitogenactivated protein kinase / J. Biol. Chem 272:10811~10816
Chen, F. H. / 2006 / Technology Insight : adult stem cells in cartilage regeneration and tissue engineering / Nat. Clin. Pract. Rheumatol 2:373~382
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