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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.7
- 수록면
- 587 - 596 (10page)
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Obesity and diabetes arise from an intricate interplay between both genetic and environmental factors. It is well recognized that obesity plays an important role in the development of insulin resistance and diabetes. Yet, the exact mechanism of the connection between obesity and diabetes is still not completely understood. Metabolomics is an analytical approach that aims to detect and quantify small metabolites. Recently, there has been an increased interest in the application of metabolomics to the identification of disease biomarkers, with a number of well-known biomarkers identified. Metabolomics is a potent approach to unravel the intricate relationships between metabolism, obesity and progression to diabetes and, at the same time, has potential as a clinical tool for risk evaluation and monitoring of disease. Moreover, metabolomics applications have revealed alterations in the levels of metabolites related to obesity-associated diabetes. This review focuses on the part that metabolomics has played in elucidating the roles of metabolites in the regulation of systemic metabolism relevant to obesity and diabetes. It also explains the possible metabolic relation and association between the two diseases. The metabolites with altered profiles in individual disorders and those that are specifically and similarly altered in both disorders are classified, categorized and summarized.
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참고문헌 (123)
참고문헌 신청
Abu Bakar, M. H. / 2015 / Metabolomics-the complementary field in systems biology : a review on obesity and type 2 diabetes / Mol. Biosyst
Adams, S. H. / 2011 / Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state / Adv. Nutr 2:445~456
Backman, L. / 1975 / Amino acid pattern in plasma before and after jejuno-ileal shunt operation for obesity / Scand J. Gastroenterol 10:811~816
Bak, J. F. / 1992 / In vivo insulin action and muscle glycogen synthase activity in type 2(non-insulin-dependent)diabetes mellitus : effects of diet treatment / Diabetologia 35:777~784
Bala, L. / 2006 / Malabsorption syndrome with and without small intestinal bacterial overgrowth : a study on upper-gut aspirate using 1H NMR spectroscopy / Magn. Reson. Med 56:738~744
Adams, S. H. / 2011 / Emerging perspectives on essential amino acid metabolism in obesity and the insulin-resistant state / Adv. Nutr 2:445~456
Backman, L. / 1975 / Amino acid pattern in plasma before and after jejuno-ileal shunt operation for obesity / Scand J. Gastroenterol 10:811~816
Bak, J. F. / 1992 / In vivo insulin action and muscle glycogen synthase activity in type 2(non-insulin-dependent)diabetes mellitus : effects of diet treatment / Diabetologia 35:777~784
Bala, L. / 2006 / Malabsorption syndrome with and without small intestinal bacterial overgrowth : a study on upper-gut aspirate using 1H NMR spectroscopy / Magn. Reson. Med 56:738~744
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