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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.2
- 수록면
- 77 - 86 (10page)
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Cancer is a heterogeneous disease caused by diverse genomic alterations in oncogenes and tumor suppressor genes. Despite recent advances in high-throughput se-quencing technologies and development of targeted therapies, novel cancer drug development is limited due to the high attrition rate from clinical studies. Patient-derived xenografts (PDX), which are established by the transfer of patient tumors into immunodeficient mice, serve as a platform for co-clinical trials by enabling the integration of clinical data, genomic profiles, and drug responsiveness data to determine precisely targeted therapies. PDX models retain many of the key characteristics of patients’ tumors including histology, genomic signature, cellular heterogeneity, and drug responsiveness. These models can also be applied to the development of biomarkers for drug responsiveness and personalized drug selection. This review summarizes our current knowledge of this field, including methodologic aspects, applications in drug development, challenges and limitations, and utilization for precision cancer medicine.
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참고문헌 (74)
참고문헌 신청
Agliano, A. / 2008 / Human acute leukemia cells injected in NOD/LtSz-scid/IL-2Rγ null mice generate a faster and more efficient disease compared to other NOD/scid-related strains / Int. J. Cancer 123:2222~2227
Aparicio, S. / 2015 / Examining the utility of patient-derived xenograft mouse models / Nat. Rev. Cancer 15:311~316
Aytes, A. / 2012 / Stromal interaction molecule 2(STIM2)is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype / Mol. Carcinog 51:746~753
Bell, D. / 2011 / Integrated genomic analyses of ovarian carcinoma / Nature 474:609~615
Bertolini, G. / 2009 / Highly tumorigenic lung cancer CD133(+)cells display stem-like features and are spared by cisplatin treatment / Proc. Natl. Acad. Sci. USA 106:16281~16286
Aparicio, S. / 2015 / Examining the utility of patient-derived xenograft mouse models / Nat. Rev. Cancer 15:311~316
Aytes, A. / 2012 / Stromal interaction molecule 2(STIM2)is frequently overexpressed in colorectal tumors and confers a tumor cell growth suppressor phenotype / Mol. Carcinog 51:746~753
Bell, D. / 2011 / Integrated genomic analyses of ovarian carcinoma / Nature 474:609~615
Bertolini, G. / 2009 / Highly tumorigenic lung cancer CD133(+)cells display stem-like features and are spared by cisplatin treatment / Proc. Natl. Acad. Sci. USA 106:16281~16286
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