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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.2
- 수록면
- 87 - 95 (9page)
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초록· 키워드
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Sirt1 is the most prominent and extensively studied member of sirtuins, the family of mammalian class III histone deacetylases heavily implicated in health span and longevity. Although primarily a nuclear protein, Sirt1’s deacetylation of Peroxisome proliferator-activated receptor Gamma Coactivator-1? (PGC-1?) has been extensively implicated in metabolic control and mitochondrial biogenesis, which was proposed to partially underlie Sirt1’s role in caloric restriction and impacts on longevity. The notion of Sirt1’s regulation of PGC-1? activity and its role in mitochondrial biogenesis has, however, been controversial. Interestingly, Sirt1 also appears to be important for the turnover of defective mitochondria by mitophagy. I discuss here evidences for Sirt1’s regulation of mitochondrial biogenesis and turnover, in relation to PGC-1? deacetylation and various aspects of cellular physiology and disease.
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참고문헌 (130)
참고문헌 신청
Albani, D. / 2009 / The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alphasynuclein or amyloid-beta(1-42)peptide / J. Neurochem 110:1445~1456
Amat, R. / 2009 / SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha(PGC-1alpha)gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD / J. Biol. Chem 284:21872~21880
Anderson, R. M. / 2008 / Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response / Aging Cell 7:101~111
Aquilano, K. / 2010 / Peroxisome proliferator-activated receptor gamma co-activator 1alpha(PGC-1alpha)and sirtuin 1(SIRT1)reside in mitochondria : possible direct function in mitochondrial biogenesis / J. Biol. Chem 285:21590~21599
Aquilano, K. / 2012 / Extranuclear localization of SIRT1 and PGC-1α : an insight into possible roles in diseases associated with mitochondrial dysfunction / Curr. Mol. Med 13:140~154
Amat, R. / 2009 / SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha(PGC-1alpha)gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD / J. Biol. Chem 284:21872~21880
Anderson, R. M. / 2008 / Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response / Aging Cell 7:101~111
Aquilano, K. / 2010 / Peroxisome proliferator-activated receptor gamma co-activator 1alpha(PGC-1alpha)and sirtuin 1(SIRT1)reside in mitochondria : possible direct function in mitochondrial biogenesis / J. Biol. Chem 285:21590~21599
Aquilano, K. / 2012 / Extranuclear localization of SIRT1 and PGC-1α : an insight into possible roles in diseases associated with mitochondrial dysfunction / Curr. Mol. Med 13:140~154
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