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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.4
- 수록면
- 345 - 351 (7page)
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Wound healing is a complex physiological process necessitating the coordinated action of various cell types, signals and microRNAs (miRNAs). However, little is known regarding the role of miRNAs in mediating this process. In the present study, we show that let-7c miRNA is decreased in heat-denatured fibroblasts and that inhibiting let-7c expression leads to the increased proliferation and migration of dermal fibroblasts, whereas the overexpression of let-7c exerts an opposite effect. Further investigation has identified heat shock protein 70 as a direct target of let-7c and has demonstrated that the expression of HSP70 in fibroblasts is negatively correlated with let-7c levels. Moreover, down-regulation of let-7c expression is accompanied by up-regulation of Bcl-2 expression and down-regulation of Bax expression, both of which are the downstream genes of HSP70. Notably, the knockdown of HSP70 by HSP70 siRNA apparently abrogates the stimulatory effect of let-7c inhibitor on heat-denatured fibroblasts proliferation and migration. Overall, we have identified let-7c as a key regulator that inhibits fibroblasts proliferation and migration during wound healing.
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등록된 정보가 없습니다.
참고문헌 (37)
참고문헌 신청
Barrientos, S. / 2008 / Growth factors and cytokines in wound healing / Wound Repair Regen 16:585~601
Bartel, D. P. / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297
Beere, H. M / 2004 / "The stress of dying" : the role of heat shock proteins in the regulation of apoptosis / J. Cell Sci 117:2641~2651
Bjorner, S. / 2014 / Epithelial and stromal microRNA signatures of columnar cell hyperplasia linking Let-7c to precancerous and cancerous breast cancer cell proliferation / PLoS One 9:105099
Calin, G. A. / 2004 / Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers / Proc. Natl. Acad. Sci. USA 101:2999~3004
Bartel, D. P. / 2004 / MicroRNAs : genomics, biogenesis, mechanism, and function / Cell 116:281~297
Beere, H. M / 2004 / "The stress of dying" : the role of heat shock proteins in the regulation of apoptosis / J. Cell Sci 117:2641~2651
Bjorner, S. / 2014 / Epithelial and stromal microRNA signatures of columnar cell hyperplasia linking Let-7c to precancerous and cancerous breast cancer cell proliferation / PLoS One 9:105099
Calin, G. A. / 2004 / Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers / Proc. Natl. Acad. Sci. USA 101:2999~3004
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