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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.11
- 수록면
- 783 - 789 (7page)
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Afflicted neurons in various neurodegenerative diseases generally display diverse and complex pathological fea-tures before catastrophic occurrence of massive neuronal loss at the late stages of the diseases. This complex nature of neuronal pathophysiology inevitably implicates systemwide changes in basic cellular activities such as transcriptional controls and signal cascades, and so on, as a cause. Recently, as one of these systemwide cellular changes associated with neurodegenerative diseases, epigenetic changes caused by protein toxicity have begun to be highlighted. Notably, recent advances in related techniques including next-generation sequencing (NGS) and mass spectrometry enable us to monitor changes in the post-translational modifications (PTMs) of histone proteins and to link these changes in histone PTMs to the specific transcriptional changes. Indeed, epigenetic alterations and consequent changes in neuronal transcriptome are now begun to be extensively studied in neurodegener-ative diseases including Alzheimer’s disease (AD). In this review, we will discuss details of our current understand-ings on epigenetic changes associated with two repre-sentative neurodegenerative diseases [AD and polygluta-mine (polyQ) diseases] and further discuss possible future development of pharmaceutical treatment of the diseases through modulating these epigenetic changes.
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참고문헌 (82)
참고문헌 신청
Agis-Balboa, R. C. / 2013 / Loss of HDAC5 impairs memory function : implications for Alzheimer’s disease / J. Alzheimers. Dis 33:35~44
Bahari-Javan, S. / 2014 / Histoneacetylation : a link between Alzheimer's disease and posttraumatic stress disorder? / Front. Neurosci 8:160
Bannister, A. J. / 2011 / Regulation of chromatin by histone modifications / Cell Res 21:381~395
Barrett, R. M. / 2011 / Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory / Neuropsychopharmacology 36:1545~1556
Bates, E. A. / 2006 / Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity / J. Neurosci 26:2830~2838
Bahari-Javan, S. / 2014 / Histoneacetylation : a link between Alzheimer's disease and posttraumatic stress disorder? / Front. Neurosci 8:160
Bannister, A. J. / 2011 / Regulation of chromatin by histone modifications / Cell Res 21:381~395
Barrett, R. M. / 2011 / Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory / Neuropsychopharmacology 36:1545~1556
Bates, E. A. / 2006 / Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity / J. Neurosci 26:2830~2838
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