지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제45권 제7호
- 발행연도
- 2015.12
- 수록면
- 611 - 624 (14page)
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초록· 키워드
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Non-invasive route for the delivery of biopharmaceuticals is one of the interesting areas in drug delivery systems. Since stratum corneum is regarded as an effective physical barrier to permeation of high molecular weight biopharmaceuticals, several methods have been studied for overcoming this problem and enhancing their permeation. The one technique for better transdermal delivery is to use drug carriers such as microemulsions, nanoemulsions, solid lipid nanoparticles and liposomes.
These carriers can facilitate the permeation of drugs by modifying physicochemical characteristics of entrapped ingredient. Liposomes are used as potential drug carriers to enhance the percutaneous absorption of various biopharmaceuticals.
Iontophoresis is another enhancing method to increase the biomembrane permeability of ionic or charged compounds using electric potential. The new strategies combining liposomes and iontophoresis technique are increasing rapidly in the field of drug delivery and possess additional benefits. It is possible to deliver neutral drugs by entrapping them in charged vehicle and their flux can be enhanced by iontophoresis. Thus, combination of liposome and iontophoresis can be effective means for transdermal permeation of biopharmaceuticals in a non-invasive and sustainable fashion.
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등록된 정보가 없습니다.
참고문헌 (179)
참고문헌 신청
Ali MFM / 2008 / Liposomal methotrexate hydrogel for treatment of localized psoriasis: preparation, characterization and laser targeting / Med Sci Monit 14:66~74
Alvarez-Figueroa M / 2001 / Transdermal delivery of methotrexate : iontophoretic delivery from hydrogels and passive delivery from microemulsions / Int J Pharm 215:57~65
Badkar A / 1999 / Enhancement of transdermal iontophoretic delivery of a liposomal formulation of colchicine by electroporation / Drug Deliv 6:111~115
Jong-Suep Baek / 2012 / The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity / Journal of Pharmaceutical Investigation 42(03):109~114
Bagniefski T / 1990 / A comparison of pulsed and continuous current iontophoresis / J Controlled Release 11:113~122
Alvarez-Figueroa M / 2001 / Transdermal delivery of methotrexate : iontophoretic delivery from hydrogels and passive delivery from microemulsions / Int J Pharm 215:57~65
Badkar A / 1999 / Enhancement of transdermal iontophoretic delivery of a liposomal formulation of colchicine by electroporation / Drug Deliv 6:111~115
Jong-Suep Baek / 2012 / The feasibility study of transdermal drug delivery systems for antidepressants possessing hydrophilicity or hydrophobicity / Journal of Pharmaceutical Investigation 42(03):109~114
Bagniefski T / 1990 / A comparison of pulsed and continuous current iontophoresis / J Controlled Release 11:113~122
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