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논문 기본 정보

자료유형
학술저널
저자정보
방현석 (포항공과대학교) 한진 (인제대학교) 서대윤 (인제대학교) 정용민 (동명대학교) 오경모 (부경대학교) 박정준 (부산대학교) Figueroa Arturo (Florida State University) 정승훈 (인제대학교) 김나리 (인제대학교)
저널정보
대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제18권 제5호
발행연도
2014.10
수록면
441 - 446 (6page)

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Ursolic acid (UA), a type of pentacyclic triterpenoid carboxylic acid purified from natural plants,can promote skeletal muscle development. We measured the effect of resistance training (RT)with/without UA on skeletal muscle development and related factors in men. Sixteen healthy maleparticipants (age, 29.37±5.14 years; body mass index=27.13±2.16 kg/m2) were randomly assigned toRT (n=7) or RT with UA (RT+UA, n=9) groups. Both groups completed 8 weeks of interventionconsisting of 5 sets of 26 exercises, with 10∼15 repetitions at 60∼80% of 1 repetition maximum anda 60∼90-s rest interval between sets, performed 6 times/week. UA or placebo was orally ingested as1 capsule 3 times/day for 8 weeks. The following factors were measured pre-and post-intervention:body composition, insulin, insulin-like growth factor-1 (IGF-1), irisin, and skeletal muscle strength. Body fat percentage was significantly decreased (p<0.001) in the RT+UA group, despite body weight,body mass index, lean body mass, glucose, and insulin levels remaining unchanged. IGF-1 and irisinwere significantly increased compared with baseline levels in the RT+UA group (p< 0.05). Maximalright and left extension (p<0.01), right flexion (p<0.05), and left flexion (p<0.001) were significantlyincreased compared with baseline levels in the RT+UA group. These findings suggest that UA-inducedelevation of serum irisin may be useful as an agent for the enhancement of skeletal muscle strengthduring RT.

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