지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제18권 제5호
- 발행연도
- 2014.10
- 수록면
- 441 - 446 (6page)
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초록· 키워드
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Ursolic acid (UA), a type of pentacyclic triterpenoid carboxylic acid purified from natural plants,can promote skeletal muscle development. We measured the effect of resistance training (RT)with/without UA on skeletal muscle development and related factors in men. Sixteen healthy maleparticipants (age, 29.37±5.14 years; body mass index=27.13±2.16 kg/m2) were randomly assigned toRT (n=7) or RT with UA (RT+UA, n=9) groups. Both groups completed 8 weeks of interventionconsisting of 5 sets of 26 exercises, with 10∼15 repetitions at 60∼80% of 1 repetition maximum anda 60∼90-s rest interval between sets, performed 6 times/week. UA or placebo was orally ingested as1 capsule 3 times/day for 8 weeks. The following factors were measured pre-and post-intervention:body composition, insulin, insulin-like growth factor-1 (IGF-1), irisin, and skeletal muscle strength.
Body fat percentage was significantly decreased (p＜0.001) in the RT+UA group, despite body weight,body mass index, lean body mass, glucose, and insulin levels remaining unchanged. IGF-1 and irisinwere significantly increased compared with baseline levels in the RT+UA group (p＜ 0.05). Maximalright and left extension (p＜0.01), right flexion (p＜0.05), and left flexion (p＜0.001) were significantlyincreased compared with baseline levels in the RT+UA group. These findings suggest that UA-inducedelevation of serum irisin may be useful as an agent for the enhancement of skeletal muscle strengthduring RT.
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참고문헌 (47)
참고문헌 신청
Yaspelkis BB 3rd / 2006 / Resistance training improves insulin signaling and action in skeletal muscle / Exerc Sport Sci Rev 34:42~46
Febbraio MA / 2005 / Contraction-induced myokine production and release: is skeletal muscle an endocrine organ? / Exerc Sport Sci Rev 33:114~119
Mormeneo E / 2012 / PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells / PLoS One 7:e29985
Boström P / 2012 / A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis / Nature 481:463~468
Kunkel SD / 2012 / Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease / PLoS One 7:e39332
Febbraio MA / 2005 / Contraction-induced myokine production and release: is skeletal muscle an endocrine organ? / Exerc Sport Sci Rev 33:114~119
Mormeneo E / 2012 / PGC-1α induces mitochondrial and myokine transcriptional programs and lipid droplet and glycogen accumulation in cultured human skeletal muscle cells / PLoS One 7:e29985
Boström P / 2012 / A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis / Nature 481:463~468
Kunkel SD / 2012 / Ursolic acid increases skeletal muscle and brown fat and decreases diet-induced obesity, glucose intolerance and fatty liver disease / PLoS One 7:e39332
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