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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.9
- 수록면
- 164 - 173 (10page)
- DOI
- 10.1186/s40824-015-0039-x
이용수
초록· 키워드
오류제보하기
Background: The aim of this study was to determine the osteoconductivity of hydroxyapatite particles (HAP) as a carrier for Escherichia coli-derived recombinant human bone morphogenetic protein-2 (ErhBMP-2). Two 8-mm diameter bicortical calvarial defects were created in each of 20 rabbits. One of each pair of defects was randomly assigned to be filled with HAP only (HAP group) or ErhBMP-2 loaded HAP (ErhBMP-2/HAP group), while the other defect was left untreated (control group). The animals were killed after either 2 weeks (n = 10) or 8 weeks (n = 10) of healing, and histological, histomorphometric, and tomographic analyses were performed. Results: All experimental sites showed uneventful healing during the postoperative healing period. In both histomorphometric and tomographic analyses, the new bone area or volume of the ErhBMP-2/HAP group was significantly greater than that of the HAP and control groups at 2 weeks (p < 0.05). However, at 8 weeks, no significant difference in new bone area or volume was observed between the ErhBMP-2/HAP and HAP groups. The total augmented area or volume was not significantly different between the ErhBMP-2/HAP and HAP groups at 2 and 8 weeks. Conclusions: Combining ErhBMP-2 with HAP could significantly promote rapid initial new bone formation. Moreover, HAP graft could increase new bone formation and space maintenance, therefore it might be one of the effective carriers of ErhBMP-2.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Ebara S. / 2002 / Mechanism for the action of bone morphogenetic proteins and regulation of their activity / Spine 27:S10~S15
Hogan BL. / 1996 / Bone morphogenetic proteins : multifunctional regulators of vertebrate development / Genes Dev 10:1580~1594
Wozney JM. / 2002 / Overview of bone morphogenetic proteins / Spine 27:S2~S8
Herford AS. / 2008 / Reconstruction of mandibular continuity defects with bone morphogenetic protein-2(rhBMP-2) / J Oral Maxillofac Surg 66:616~624
Lan J. / 2007 / The influence of recombinant human BMP-2 on bone-implant osseointegration : biomechanical testing and histomorphometric analysis / Int J Oral Maxillofac Surg 36:345~349
Hogan BL. / 1996 / Bone morphogenetic proteins : multifunctional regulators of vertebrate development / Genes Dev 10:1580~1594
Wozney JM. / 2002 / Overview of bone morphogenetic proteins / Spine 27:S2~S8
Herford AS. / 2008 / Reconstruction of mandibular continuity defects with bone morphogenetic protein-2(rhBMP-2) / J Oral Maxillofac Surg 66:616~624
Lan J. / 2007 / The influence of recombinant human BMP-2 on bone-implant osseointegration : biomechanical testing and histomorphometric analysis / Int J Oral Maxillofac Surg 36:345~349
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