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논문 기본 정보

자료유형
학술저널
저자정보
Sagar N Kaushik (University of Alabama at Birmingham Birmingham) Bogeun Kim (University of Alabama at Birmingham) Alexander M. Cruz Walma (University of Alabama at Birmingham) Sung Chul Choi (Kyung Hee University) Hui Wu (University of Alabama at Birmingham) Jeremy J. Mao (Center for Craniofacial Regeneration at Columbia U) Ho-Wook Jun (University of Alabama at Birmingham) Kyounga Cheon (University of Alabama at Birmingham)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제20권 제2호
발행연도
2016.6
수록면
76 - 87 (12page)
DOI
10.1186/s40824-016-0061-7

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Regenerative endodontics has been proposed to replace damaged and underdeveloped tooth structures with normal pulp-dentin tissue by providing a natural extracellular matrix (ECM) mimicking environment; stem cells, signaling molecules, and scaffolds. In addition, clinical success of the regenerative endodontic treatments can be evidenced by absence of signs and symptoms; no bony pathology, a disinfected pulp, and the maturation of root dentin in length and thickness. In spite of the various approaches of regenerative endodontics, there are several major challenges that remain to be improved: a) the endodontic root canal is a strong harbor of the endodontic bacterial biofilm and the fundamental etiologic factors of recurrent endodontic diseases, (b) tooth discolorations are caused by antibiotics and filling materials, (c) cervical root fractures are caused by endodontic medicaments, (d) pulp tissue is not vascularized nor innervated, and (e) the dentin matrix is not developed with adequate root thickness and length. Generally, current clinical protocols and recent studies have shown a limited success of the pulp-dentin tissue regeneration. Throughout the various approaches, the construction of biomimetic microenvironments of pulp-dentin tissue is a key concept of the tissue engineering based regenerative endodontics. The biomimetic microenvironments are composed of a synthetic nano-scaled polymeric fiber structure that mimics native pulp ECM and functions as a scaffold of the pulp-dentin tissue complex. They will provide a framework of the pulp ECM, can deliver selective bioactive molecules, and may recruit pluripotent stem cells from the vicinity of the pulp apex. The polymeric nanofibers are produced by methods of self-assembly, electrospinning, and phase separation. In order to be applied to biomedical use, the polymeric nanofibers require biocompatibility, stability, and biodegradability. Therefore, this review focuses on the development and application of the biomimetic microenvironments of pulp-dentin tissue among the current regenerative endodontics.

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