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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.9
- 수록면
- 132 - 141 (10page)
- DOI
- 10.1186/s40824-016-0067-1
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초록· 키워드
오류제보하기
T cells play a central role in immune-homeostasis; specifically in the induction of antigen-specific adaptive immunity against pathogens and mutated self with immunological memory. The thymus is the unique organ where T cells are generated. In this review, first the complex structures and functions of various thymic microcompartments are briefly discussed to identify critical engineering targets for regeneration of thymic functions in vitro and in vivo. Then the biomimetic regenerative engineering approaches are reviewed in three categories: 1) reconstruction of 3-D thymic architecture, 2) cellular engineering, and 3) biomaterials-based artificial presentation of critical biomolecules. For each engineering approach, remaining challenges and clinical opportunities are also identified and discussed.
목차
등록된 정보가 없습니다.
참고문헌 (88)
참고문헌 신청
Miller JF / 2002 / The discovery of thymus function and of thymus-derived lymphocytes / Immunol Rev 185:7~14
Petrie HT / 2002 / Role of thymic organ structure and stromal composition in steady-state postnatal T-cell production / Immunol Rev 189:8~19
Seach N / 2007 / Thymic generation and regeneration : a new paradigm for establishing clinical tolerance of stem cell-based therapies / Curr Opin Biotechnol 18(5):441~447
Gray DH / 2005 / Controlling the thymic microenvironment / Curr Opin Immunol 17(2):137~143
Ladi E / 2006 / Thymic microenvironments for T cell differentiation and selection / Nat Immunol 7(4):338~343
Petrie HT / 2002 / Role of thymic organ structure and stromal composition in steady-state postnatal T-cell production / Immunol Rev 189:8~19
Seach N / 2007 / Thymic generation and regeneration : a new paradigm for establishing clinical tolerance of stem cell-based therapies / Curr Opin Biotechnol 18(5):441~447
Gray DH / 2005 / Controlling the thymic microenvironment / Curr Opin Immunol 17(2):137~143
Ladi E / 2006 / Thymic microenvironments for T cell differentiation and selection / Nat Immunol 7(4):338~343
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