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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 213 - 221 (9page)
- DOI
- 10.1186/s40824-016-0081-3
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초록· 키워드
오류제보하기
The use of poly(lactic-co-glycolic acid) (PLGA)-based nanocarriers presents several major challenges, including their synthetic hydrophobic surface, low transfection efficiency, short circulation half-life, and nonspecific tissue distribution. Numerous engineering strategies have been employed to overcome these problems, with lipid-based surface functionalization of PLGA nanoparticles (NPs) showing promising results in the development of PLGA-based clinical nanomedicines. Surface engineering with different lipids enhances the target specificity of the carrier and improves its physicochemical properties as well as NP-cell associations, such as cellular membrane permeability, immune responses, and long circulation half-life in vivo. This review focuses on recent advances in the lipid-based surface engineering of PLGA NPs for drug and gene delivery applications.
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등록된 정보가 없습니다.
참고문헌 (64)
참고문헌 신청
Farokhzad OC / 2006 / Nanomedicine : developing smarter therapeutic and diagnostic modalities / Adv Drug Deliv Rev 58:1456~1459
Li Li / 2015 / Polymeric nanocarrier systems for photodynamic therapy / 생체재료학회지 19(1):01~14
Bose RJC / 2014 / Fabrication and characterization of PLGA polymer-lipid hybrid nanoparticle for gene delivery platform / The Polymer Society of Korea Proceedings of 2014 Spring Conference paper :60
Udomluck N / 2015 / Poly (N-isopropylacrylamide)-based nanogels encapsulating gold nanoparticles for DNA delivery / J Control Release 213:e85
Danhier F / 2012 / PLGA-based nanoparticles : an overview of biomedical applications / J Control Release 161:505~522
Li Li / 2015 / Polymeric nanocarrier systems for photodynamic therapy / 생체재료학회지 19(1):01~14
Bose RJC / 2014 / Fabrication and characterization of PLGA polymer-lipid hybrid nanoparticle for gene delivery platform / The Polymer Society of Korea Proceedings of 2014 Spring Conference paper :60
Udomluck N / 2015 / Poly (N-isopropylacrylamide)-based nanogels encapsulating gold nanoparticles for DNA delivery / J Control Release 213:e85
Danhier F / 2012 / PLGA-based nanoparticles : an overview of biomedical applications / J Control Release 161:505~522
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