The Roles of Modern Breast Imaging Techniques for Evaluation of Lobular Carcinoma In Situ of the Breast

Hanjong Shin; Han-Byoel Lee; Wonshik Han; Dong-Young Noh; Hyeong-Gon Moon

doi:http://dx.doi.org/10.14449/jbd.2015.3.2.71

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자료유형: 학술저널

저자정보: Hanjong Shin (Department of Surgery and 2Cancer Research Institute Seoul National University College of Medicine) Han-Byoel Lee (Department of Surgery and 2Cancer Research Institute Seoul National University College of Medicine) Wonshik Han (Department of Surgery and Cancer Research Institute Seoul National University College of Medicine) Dong-Young Noh (Department of Surgery and Cancer Research Institute Seoul National University College of Medicine) Hyeong-Gon Moon (Department of Surgery and Cancer Research Institute Seoul National University College of Medicine)

저널정보: 한국유방암학회 Journal of Breast Disease Journal of Breast Disease 제3권 제2호

발행연도: 2015.12

수록면: 71 - 76 (6page)

DOI: http://dx.doi.org/10.14449/jbd.2015.3.2.71

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Purpose: We aimed to evaluate the incidence of multifocal and bilateral lobular carcinoma in situ (LCIS) of the breast in Korean women. Add-itionally, we explored the characteristics of current breast imaging studies and evaluated their roles in detecting multifocal and bilateral lesions in LCIS patients. Methods: Between January 2000 and December 2013, we identified 48 patients with pure LCIS who underwent curative surgery at our institution. The pathological findings and the results of various imaging studies were reviewed. Results: All patients underwent mammography and ultrasonography prior to surgery, and 35 patients (72.9%) also received breast magnetic resonance imaging (MRI). The most common radiologic features of LCIS were the presence of microcalcifications (66.7%) and irregularly shaped masses (64.6%) on mammography and ultrasonography, respectively. MRI often showed the presence of irregularly enhanced mass-like lesions (91.4%). Add-itional suspicious lesions in the ipsilateral breast were identified in 19 (39.6%) and 16 (45.7%) patients on ultrasonography and MRI, respectively. Among them, nine (47.4%) were malignant lesions. In the contralateral breast, there were 14 (29.2%) and 11 (31.4%) lesions requiring biopsy on ultrasonography and MRI, respectively, and eight of these were found to be malignant lesions. All suspicious lesions detected by MRI were also seen on ultrasonography. In total, 20.8% (10/48) of the patients had ipsilateral LCIS, and 16.7% (8/48) had contralateral malignancies. Conclusion: Our study demonstrates that in Korean women, LCIS is associated with a high incidence of ipsilateral and contralateral malignancies. However, breast MRI had a limited role in detecting additional malignant tumors in LCIS patients.

#Breast #Lobular carcinoma in situ #Magnetic resonance imaging #Ultrasonography

참고문헌 (19)

참고문헌 신청

Ewing J / 1919 / Neoplastic Diseases: A Text-book on Tumors / W.B. Saunders Company

Foote FW / 1941 / Lobular carcinoma in situ: a rare form of mammary cancer / Am J Pathol 17:491~496.3

Haagensen CD / 1978 / Lobular neoplasia (so-called lobular carcinoma in situ) of the breast / Cancer 42:737~769

Dupont WD / 1985 / Risk factors for breast cancer in women with proliferative breast disease / N Engl J Med 312:146~151

Page DL / 2003 / Atypical lobular hyperplasia as a unilateral predictor of breast cancer risk: a retrospective cohort study / Lancet 361:125~129

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Hanjong Shin

소속기관 Department of Surgery and 2Cancer Research Institute Seoul National University College of Medicine