지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.9
- 수록면
- 26 - 34 (9page)
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초록· 키워드
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Background: Fluralaner is a novel drug belonging to the isoxazoline class that acts on external parasites of domestic animals. It is used systemically via drinking water, especially against red poultry mite in layer chickens. Fluralaner is frequently used in layers infected with D. gallinae. However, no study to date has investigated the effects of feed intake and water hardness.
Objectives: This study aimed to investigate the effects of variable water hardness and feed intake on the pharmacokinetic profile of fluralaner.
Methods: Layer chickens were divided into four groups (n = 8): fed + purified water (Group 1), feed restricted + purified water (Group 2), feed restricted + hard water (Group 3), and feed restricted + soft water (Group 4). After administering a single dose of the drug with drinking water, the blood samples were collected for 21 days. Fluralaner concentrations in plasma samples were determined by liquid chromatography/tandem mass spectrometry. The maximum plasma concentration (C<SUB>max</SUB>), time to reach maximum plasma concentration (t<SUB>max</SUB>), area under the concentration–time curve values (AUC<SUB>0-21d</SUB>), half-life (t<SUB>1/2</SUB>), and other pharmacokinetic parameters were calculated.
Results: Although the highest maximum plasma concentration (C<SUB>max</SUB>) was determined in Group 1 (fed + purified water), no statistically significant difference was found in the C<SUB>max</SUB>, t<SUB>max</SUB>, t<SUB>1/2</SUB>, MRT<SUB>0-inf_obs</SUB>, Vz/F<SUB>obs</SUB>, and Cl/F_<SUB>obs</SUB> parameters between the experimental groups.
Conclusions: It was concluded that the feed intake or water hardness did not change the pharmacokinetic profile of fluralaner in layer chickens. Therefore, fluralaner could be used before or after feeding with the varying water hardness in poultry industry.
Objectives: This study aimed to investigate the effects of variable water hardness and feed intake on the pharmacokinetic profile of fluralaner.
Methods: Layer chickens were divided into four groups (n = 8): fed + purified water (Group 1), feed restricted + purified water (Group 2), feed restricted + hard water (Group 3), and feed restricted + soft water (Group 4). After administering a single dose of the drug with drinking water, the blood samples were collected for 21 days. Fluralaner concentrations in plasma samples were determined by liquid chromatography/tandem mass spectrometry. The maximum plasma concentration (C<SUB>max</SUB>), time to reach maximum plasma concentration (t<SUB>max</SUB>), area under the concentration–time curve values (AUC<SUB>0-21d</SUB>), half-life (t<SUB>1/2</SUB>), and other pharmacokinetic parameters were calculated.
Results: Although the highest maximum plasma concentration (C<SUB>max</SUB>) was determined in Group 1 (fed + purified water), no statistically significant difference was found in the C<SUB>max</SUB>, t<SUB>max</SUB>, t<SUB>1/2</SUB>, MRT<SUB>0-inf_obs</SUB>, Vz/F<SUB>obs</SUB>, and Cl/F_<SUB>obs</SUB> parameters between the experimental groups.
Conclusions: It was concluded that the feed intake or water hardness did not change the pharmacokinetic profile of fluralaner in layer chickens. Therefore, fluralaner could be used before or after feeding with the varying water hardness in poultry industry.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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