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논문 기본 정보

자료유형
학술저널
저자정보
Darlene Mae D. Ortiz (Sahmyook University) Hyeyeon Oh (Sahmyook University) Soonyong Kwon (Sahmyook University) Eunseon Jeon (Sahmyook University) Muhammad Kamal Hossain (Jeonbuk National University) Hee Jin Kim (Sahmyook University) Mikyung Kim (Sahmyook University)
저널정보
한국생약학회 Natural Product Sciences Natural Product Sciences Vol.29 No.3
발행연도
2023.9
수록면
138 - 145 (8page)
DOI
10.20307/nps.2023.29.3.138

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초록· 키워드

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Sleep deprivation or insomnia is one of the most common but neglected health conditions, with serious long-term consequences. In addition, insomnia is linked to poor work performance, impaired memory, and lack of concentration. Improving sleep quality is a crucial aspect of health care. Hypnotic agents, such as benzodiazepines, antidepressants, and antihistamines, are often used to enhance sleep quality; however, these medications often result in tolerance and dependence, resulting in withdrawal syndrome upon discontinuation. In recent years, studies have focused on natural and herbal therapies as alternative sleep aids to overcome the adverse effects of available sleep medications. Plant extracts contain phytochemicals that exert anxiolytic and sedative properties. This includes Passiflora incarnata (FSD-PI) and Lactuca sativa L. (FSD-LS) which can induce sleep. Herein, we assessed the effects of natural products, FSD-PI and FSD-LS, as well as their synergistic effects on pentobarbital sleep-induced ICR mice. We observed that natural extracts did not cause any behavioral changes capable of negative effects in mice. Furthermore, sleep duration was prolonged in pentobarbital-treated mice administered with FSD-LS (100 mg/kg). Our data suggest that FSD-LS may be a safe and effective sleep promoter.

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Abstract 
Introduction
Experimental
Results and Discussion
References

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