지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 1,182 - 1,192 (11page)
- DOI
- 10.1038/s12276-023-01003-2
이용수
초록· 키워드
오류제보하기
Spinal cord injury (SCI) is a clinical condition that leads to permanent and/or progressive disabilities of sensory, motor, and autonomic functions. Unfortunately, no medical standard of care for SCI exists to reverse the damage. Here, we assessed the effects of induced neural stem cells (iNSCs) directly converted from human urine cells (UCs) in SCI rat models. We successfully generated iNSCs from human UCs, commercial fibroblasts, and patient-derived fibroblasts. These iNSCs expressed various neural stem cell markers and differentiated into diverse neuronal and glial cell types. When transplanted into injured spinal cords, UC-derived iNSCs survived, engrafted, and expressed neuronal and glial markers. Large numbers of axons extended from grafts over long distances, leading to connections between host and graft neurons at 8 weeks post-transplantation with significant improvement of locomotor function. This study suggests that iNSCs have biomedical applications for disease modeling and constitute an alternative transplantation strategy as a personalized cell source for neural regeneration in several spinal cord diseases.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Generation of induced neural stem cells from human fibroblast
한국생물공학회 학술대회
2019 .04
-
Treatment of Syringomyelia Characterized by Focal Dilatation of the Central Canal Using Mesenchymal Stem Cells and Neural Stem Cells
조직공학과 재생의학
2024 .06
-
Effect of Bone Fragment Impact Velocity on Biomechanical Parameters of the Spinal Cord
대한기계학회 춘추학술대회
2015 .05
-
Combined Method of Neuronal Cell-Inducible Vector and Valproic Acid for Enhanced Gene Expression under Hypoxic Conditions
조직공학과 재생의학
2020 .01
-
Effects of PTP sigma on glial scar formation in spinal cord injury model
한국생물공학회 학술대회
2019 .10
-
Transplantation of Wnt5a-modified NSCs promotes tissue repair and locomotor functional recovery after spinal cord injury
Experimental and Molecular Medicine
2020 .12
-
Vascular Endothelial Growth Factor Enhances Axonal Outgrowth in Organotypic Spinal Cord Slices via Vascular Endothelial Growth Factor Receptor 1 and 2
조직공학과 재생의학
2016 .01
-
Static and Dynamic Anthropometric Measurements of Individuals with Spinal Cord Injury
한국재활복지공학회 학술대회 논문집
2020 .11
-
Stem cell therapy for Alzheimer’s disease and related disorders: current status and future perspectives
Experimental and Molecular Medicine
2015 .01
-
Investigation of individual fingertip forces trend between healthy and spinal cord injury patients
한국재활복지공학회 학술대회 논문집
2019 .11
-
Sleep Monitoring for Individuals with Spinal Cord Injury using Contact-Free Bed Sensors
한국재활복지공학회 학술대회 논문집
2021 .11
-
Biomechanical investigation of contusion, dislocation, and distraction spinal cord injury mechanisms
대한기계학회 춘추학술대회
2017 .04
-
Stem Cell Tracing Through MR Molecular Imaging
조직공학과 재생의학
2018 .01
-
척수손상장애인의 낙상 효능 검사와 기계적 외골격 착용에 따른 균형 상관성 연구
한국정밀공학회 학술발표대회 논문집
2019 .05
-
Development of the Wearable Walking Robot for Spinal Cord Injury, RoboWear10 the 2017 17th International Conference on Control, Automation and Systems (ICCAS 2017)
제어로봇시스템학회 국제학술대회 논문집
2017 .10
-
Differentiation of human gingival mesenchymal stem cells into neuronal lineages in 3D bioconjugated injectable protein hydrogel construct for the management of neuronal disorder
Experimental and Molecular Medicine
2016 .01
-
경수손상장애인의 스마트모니터링/코칭 요구 분석에 관한 연구
한국정밀공학회 학술발표대회 논문집
2019 .05
-
In vitro monitoring of neural stem cell differentiation based on surface-enhanced Raman spectroscopy
한국생물공학회 학술대회
2016 .04
-
척수 손상 환자의 하지 근육 물성치 특성
한국정밀공학회 학술발표대회 논문집
2016 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0