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논문 기본 정보

자료유형
학술저널
저자정보
Yazdi Saeideh Izadi (Islamic Azad University) Sadeghi Mahdi (Iran University of Medical Sciences) Saeedzadeh Elham (Islamic Azad University) Jalilifar Mostafa (Iran University of Medical Sciences)
저널정보
한국원자력학회 Nuclear Engineering and Technology Nuclear Engineering and Technology 제55권 제4호
발행연도
2023.4
수록면
1,265 - 1,268 (4page)
DOI
10.1016/j.net.2022.12.037

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초록· 키워드

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One important issue in using radiopharmaceuticals as therapeutic and imaging agents is predicting different organ absorbed dose following their injection. The present study aims at extrapolating dosimetry estimates to a female phantom from the animal data of 89Zr radionuclide accumulation using the Sparks-Idogan relationship. The absorbed dose of 89Zr radionuclide in different organs of the human body was calculated based on its distribution data in mice using both MIRD method and the MCNP simulation code. In this study, breasts, liver, heart wall, stomach, kidneys, lungs and spleen were considered as source and target organs. The highest and the lowest absorbed doses were respectively delivered to the liver (4.00E-02 and 3.43E-02 mGy/MBq) and the stomach (1.83E-03 and 1.66E-03 mGy/MBq). Moreover, there was a good agreement between the results obtained from both MIRD and MCNP methods. Therefore, according to the dosimetry results, [89Zr] DFO-CR011-PET/CT seems to be a suitable for diagnostic imaging of the breast anomalies for CDX-011 targeting gpNMB in patients with TNBC in the future.

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