The Clinical Characteristic and Management of Patients with Nocardiosis in a Tertiary Hospital in China

Liu Peilin; Wang Zhiqian; Jian Zijuan; Liu Xuan; Li Yanming; Yan Qun; Zhong Baiyun; Liao Mengting; Liang Xianghui; Liu Wenen

doi:10.4014/jmb.2209.09034

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저자정보: Liu Peilin (Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. ChinaNational Clinical Research Center for Geriatric Disorders) Wang Zhiqian (Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. China) Jian Zijuan (Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. China) Liu Xuan (Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. China) Li Yanming (Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. China) Yan Qun (Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. China) Zhong Baiyun (Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. China) Liao Mengting (Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. China) Liang Xianghui (Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. China) Liu Wenen (Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. ChinaNational Clinical Research Center for Geriatric Disorders)

저널정보: 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제33권 제5호

발행연도: 2023.5

수록면: 574 - 581 (8page)

DOI: 10.4014/jmb.2209.09034

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Nocardiosis is an uncommon opportunistic bacterial infection which becomes a significant health problem due to its increasing incidence and high mortality rate. However, many nocardiosis patients are underdiagnosed by physicians. To summarize the clinical characteristics and management of nocardiosis would help with better diagnosis and prognosis of nocardiosis. This retrospective study was conducted based on the medical records of nocardiosis patients between January 2015 and December 2021 in a tertiary hospital in China. Overall, 44 nocardiosis patients with 54 specimens were included. The patients consisted of 26 males and 18 females with a mean age of 50.4 ± 13.2 years. Among 44 patients, 26 (59.1%) were previously given immunosuppressive therapy. Connective tissue diseases (CTDs) were the most common underlying disease (16/44). The most frequent infection sites were the lungs (17/44) and skin or soft tissues (8/44). Common symptoms included cough (23/44), expectoration (18/44), fever (15/44), and subcutaneous abscesses (15/44). Forty-five out of 54 specimens (83.3%) required over 48 hours of culture time for nocardiosis detection. Thirty-six patients were cured or improved, 5 patients were discharged from the hospital due to poor prognosis, and 1 patient died. The average diagnosis time of poor prognosis cases was 19.7 days, which was significantly longer than those of improved or cured patients (7.3 days). Immunosuppressed patients comprise a large part of nocardiosis cases, which is worth attention in clinical practice. Early diagnosis, specifically through prolonged cultivation time of specimen, could help achieve better prognosis of nocardiosis patients.

#Nocardia #Nocardiosis #clinical characteristic #immunosuppressed patients #early diagnosis

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Liu Peilin

소속기관 Department of Clinical Laboratory Xiangya Hospital Central South University No.87 Xiangya Road Kaifu district Changsha 410008 Hunan P.R. ChinaNational Clinical Research Center for Geriatric Disorders

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Wang Zhiqian