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자료유형
학술저널
저자정보
Seong Hye (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea.AIDS Research Institute Yonsei University College of Medicine Seoul Korea.Department of Internal Medicine Korea Univer) Choi Yunsu (Department of Preventive Medicine Hanyang University College of Medicine Seoul Korea.Institute for Health and Society Hanyang University Seoul Korea.) Kim Minjeong (Division of Data Technology Tokyo Electron Korea Ltd Hwaseong Gyeonggi-do Korea.) Kim Jung Ho (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea.AIDS Research Institute Yonsei University College of Medicine Seoul Korea.) Song Joon Young (Department of Internal Medicine Korea University College of Medicine Seoul Korea.) 김신우 (Department of Internal Medicine Kyungpook National University School of Medicine Daegu Korea.) Kim Sang Il (Department of Internal Medicine Seoul St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea.) Kim Youn Jeong (Department of Internal Medicine Incheon St. Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea.) Park Dae Won (Department of Internal Medicine Korea University College of Medicine Seoul Korea.) Park Boyoung (Department of Preventive Medicine Hanyang University College of Medicine Seoul Korea.Hanyang Institute of Bioscience and Biotechnology Hanyang University Seoul Korea.) Choi Bo Youl (Department of Preventive Medicine Hanyang University College of Medicine Seoul Korea.Institute for Health and Society Hanyang University Seoul Korea.) Choi Jun-Yong (Department of Internal Medicine Yonsei University College of Medicine Seoul Korea.AIDS Research Institute Yonsei University College of Medicine Seoul Korea.)
저널정보
대한감염학회 Infection and Chemotherapy Infection and Chemotherapy 제55권 제1호
발행연도
2023.3
수록면
69 - 79 (11page)
DOI
10.3947/ic.2022.0059

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Background Owing to antiretroviral therapy (ART), acquired immune deficiency syndrome (AIDS)-related mortality has significantly decreased. Retaining in care is an essential step for human immunodeficiency virus (HIV) care cascade. This study investigated the incidence of and risk factors for loss to follow-up (LTFU) in Korean people living with HIV (PLWH). Materials and Methods Data from the Korea HIV/AIDS cohort study (including prospective interval cohort and retrospective clinical cohort) were analyzed. LTFU was defined as not visiting the clinic for more than 1 year. Risk factors for LTFU were identified using the Cox regression hazard model. Results The study enrolled 3,172 adult HIV patients (median age, 36 years; male 92.97%). The median CD4 T cell count at enrollment was 234 cells/mm3 (interquartile range [IQR]: 85 - 373) and the median viral load at enrollment was 56,100 copies/mL (IQR: 15,000 - 203,992). The total follow-up duration was 16,487 person-years, and the overall incidence rate of LTFU was 85/1,000 person-years. In the multivariable Cox regression model, subjects on ART were less likely to have LTFU than subjects not on ART (hazard ratio [HR] = 0.253, 95% confidence interval [CI]: 0.220 - 0.291, P <0.0001). Among PLWH on ART, female sex (HR = 0.752, 95% CI: 0.582 - 0.971, P = 0.0291) and older age (>50: HR = 0.732, 95% CI: 0.602 - 0.890; 41 - 50: HR = 0.634, 95% CI: 0.530 - 0.750; 31 - 40: HR = 0.724, 95% CI: 0.618 - 0.847; ≤30: reference, P <0.0001) were associated with high rate of retention in care. The viral load at ART initiation ≥1,000,001 (HR = 1.545, 95% CI: 1.126 - 2.121, ≤10,000: reference) was associated with a higher rate of LTFU. Conclusion Young and male PLWH may have a higher rate of LTFU, and an increased rate of LTFU may induce virologic failure.

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