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논문 기본 정보

자료유형
학술저널
저자정보
Yamei Xu (Department of Pathology College of Basic Medicine Chongqing Medical University) Qiyuan Hu (Department of Pathology College of Basic Medicine Chongqing Medical University) Zongyun Wei (Department of Pathology College of Basic Medicine Chongqing Medical University) Yi Ou (Department of Pathology College of Basic Medicine Chongqing Medical University) Youde Cao (Department of Pathology College of Basic Medicine Chongqing Medical University) Hang Zhou (Department of Pathology College of Basic Medicine Chongqing Medical University) Mengna Wang (Department of Pathology College of Basic Medicine Chongqing Medical University) Kexiao Yu (Department of Orthopedics Chongqing Traditional Chinese Medicine Hospital) Bing Liang (Department of Pathology College of Basic Medicine Chongqing Medical University)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
1,011 - 1,058 (48page)
DOI
https://doi.org/10.1186/s40824-023-00379-6

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Diabetic ulcers (DUs) are one of the most serious complications of diabetes mellitus. The application of a functional dressing is a crucial step in DU treatment and is associated with the patient’s recovery and prognosis. However, traditional dressings with a simple structure and a single function cannot meet clinical requirements. Therefore, researchers have turned their attention to advanced polymer dressings and hydrogels to solve the therapeutic bottleneck of DU treatment. Hydrogels are a class of gels with a three-dimensional network structure that have good moisturizing properties and permeability and promote autolytic debridement and material exchange. Moreover, hydrogels mimic the natural environment of the extracellular matrix, providing suitable surroundings for cell proliferation. Thus, hydrogels with different mechanical strengths and biological properties have been extensively explored as DU dressing platforms. In this review, we define different types of hydrogels and elaborate the mechanisms by which they repair DUs. Moreover, we summarize the pathological process of DUs and review various additives used for their treatment. Finally, we examine the limitations and obstacles that exist in the development of the clinically relevant applications of these appealing technologies.

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