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논문 기본 정보

자료유형
학술저널
저자정보
Shiyao Fu (School of Medicine and Health Harbin Institute of Technology) Mingao Wang (Department of Nephrology the First Afliated Hospital of Harbin Medical University) Bin Li (Academician Workstation Jiangxi University of Traditional Chinese Medicine) Xu Li (Department of Ophthalmology the Second Hospital of Jilin University) Jianjun Cheng (School of Chemistry and Chemical Engineering Harbin Institute of Technology) Haitian Zhao (School of Medicine and Health Harbin Institute of Technology) Hua Zhang (School of Chemistry and Chemical Engineering Harbin Institute of Technology) Aijun Dong (School of Chemistry and Chemical Engineering Harbin Institute of Technology) Weihong Lu (School of Medicine and Health Harbin Institute of Technology) Xin Yang (School of Medicine and Health Harbin Institute of Technology)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
1,199 - 1,218 (20page)
DOI
https://doi.org/10.1186/s40824-023-00380-z

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Background Multi-component nano-delivery systems based on chemotherapy (chemo)- photodynamic therapy (PDT)- chemodynamic therapy (CDT) have gained increased attention as a promising strategy to improve clinical outcomes in cancer treatment. However, there remains a challenge in developing biodegradable, biocompatible, less toxic, yet highly efficient multicomponent nanobased drug delivery systems (DDS). Here, our study presents the screening and development of a novel DDS based on co-assemblies natural small molecule (NSMs). These molecules (oleanolic acid, and betulinic acid) are combined with photosensitizers Chlorine6 (Ce6) and Cu2+ that are encapsulated by tumor cell membranes. This nanocarrier encapsulated in tumor cell membranes achieved good tumor targeting and a significant improvement in tumor accumulation. Methods A reprecipitation method was used to prepare the co-assembled nanocarrier, followed by the introduction of Cu2 + into the DDS (OABACe6 NPs). Then, by wrapping the surface of NPs with the cell membranes of 4T1 which is a kind of mouse breast cancer cells (CM@OABACe6/Cu NPs). and analysis of its structure and size distribution with UV–Vis, XPS, FT-IR, SEM, TEM, and DLS. The synergistic effects of in vitro chemotherapy, CDT and PDT and targeting were also validated by cellular and animal studies. Results It was shown that CM@OABACe6/Cu NPs achieved good tumor targeting and a significant improvement in tumor accumulation. In the composite nano-assembly, the NSMs work together with the Ce6 to provide effective and safe chemo and PDT. Moreover, the effect of reduced PDT due to the depletion of reactive oxygen species (ROS) by excess glutathione (GSH) in the tumor can be counteracted when Cu2 + is introduced. More importantly, it also confers CDT through a Fenton-like catalytic reaction with H2O overexpressed at the tumor site. Conclusions By constructing CM@OABACe6/Cu NPs with homologous targeting, we create a triple synergistic platform for cancer therapy using PDT, chemo, and CDT. We propose here a novel combinatorial strategy for designing more naturally co-assembled small molecules, especially for the development of multifunctional synergistic therapies that utilize NSMs.
#Triterpenoids #Co-assemblies #4T1 cell membrane #Synergistic cancer treatment

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