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논문 기본 정보

자료유형
학술저널
저자정보
Poojitha Pinjala (Molecular and Cellular Neuroscience Lab Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad) Kamatham Pushpa Tryphena (Molecular and Cellular Neuroscience Lab Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad) Renuka Prasad (Department of Anatomy Korea University College of Medicine Moonsuk Medical Research Building) Dharmendra Kumar Khatri (Molecular and Cellular Neuroscience Lab Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad) 선웅 (고려대학교) Shashi Bala Singh (Molecular and Cellular Neuroscience Lab Department of Pharmacology and Toxicology National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad) Dalapathi Gugulothu (Department of Pharmaceutics Delhi Pharmaceutical Sciences and Research University (DPSRU)) Saurabh Srivastava (Department of Pharmaceutics National Institute of Pharmaceutical Education and Research (NIPER)-Hyderabad) Lalitkumar Vora (School of Pharmacy Queen’s University Belfast)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
1,273 - 1,290 (18page)
DOI
https://doi.org/10.1186/s40824-023-00381-y

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Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to correct the causative gene mutation and establish animal models in neurodegenerative disorders. Since no strategy developed until now could completely cure Parkinson’s disease (PD), neuroscientists aspire to use gene editing technology, especially CRISPR/Cas9, to induce a permanent correction in genetic PD patients expressing mutated genes. Over the years, our understanding of stem cell biology has improved. Scientists have developed personalized cell therapy using CRISPR/Cas9 to edit embryonic and patient-derived stem cells ex-vivo. This review details the importance of CRISPR/Cas9-based stem cell therapy in Parkinson’s disease in developing PD disease models and developing therapeutic strategies after elucidating the possible pathophysiological mechanisms.

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