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논문 기본 정보

자료유형
학술저널
저자정보
Wu Hao (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine) Wei Guoli (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine) Luo Lixia (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine) Li Lingchang (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine) Gao Yibo (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine) Tan Xiaobin (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine) Wang Sen (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine) Chang Haoxiao (Department of Neu rology Beijing Tiantan Hospital Capital Medical University) Liu Yuxi (School of Material Science and Chemical Engineering Chuzhou University) Wei Yingjie (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine) Song Jie (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine) Zhang Zhenhai (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine) Huo Jiege (Afliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제27권
발행연도
2023.3
수록면
98 - 118 (21page)
DOI
10.1186/s40824-022-00329-8

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Combination of chemotherapy and immune checkpoint inhibitor therapy has greatly improved the anticancer effect on multiple malignancies. However, the efficiency on triple-negative breast cancer (TNBC) is limited, since most patients bear “cold” tumors with low tumor immunogenicity. Doxorubicin (DOX), one of the most effective chemotherapy agents, can induce immunogenic cell death (ICD) and thus initiating immune response.In this study, to maximize the ICD effect induced by DOX, chitosan and cell-penetrating peptide (R6F3)-modified nanoparticles (PNPs) loaded with ginsenoside Rg3 (Rg3) were fabricated using the self-assembly technique, followed by co-encapsulation with DOX based on thermo-sensitive hydrogel. Orthotopic tumor model and contralateral tumor model were established to observe the antitumor efficacy of the thermo-sensitive hydrogel combined with anti-PD-L1 immunotherapy, besides, the biocompatibility was also evaluated by histopathological.Rg3-PNPs strengthened the immunogenic cell death (ICD) effect induced by DOX. Moreover, the hydrogel co-loading Rg3-PNPs and DOX provoked stronger immune response in originally nonimmunogenic 4T1 tumors than DOX monotherapy. Following combination with PD-L1 blocking, substantial antitumor effect was achieved due to the recruitment of memory T cells and the decline of adaptive PD-L1 enrichment.The hydrogel encapsulating DOX and highly permeable Rg3-PNPs provided an efficient strategy for remodeling immunosuppressive tumor microenvironment and converting immune “cold” 4T1 into “hot” tumors.
#Chitosan #Thermo-sensitive hydrogel #Immunochemotherapy #Immunogenic cell death #Doxorubicin #Ginsenoside Rg3

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