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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2023.6
- 수록면
- 77 - 86 (10page)
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Advanced glycation end-products (AGEs) are compounds naturally produced in the body during the glycation reaction. Excessive AGEs bind to long-lived proteins such as collagen and accumulate in the body, leading to AGEs related diabetic complications. This study aimed to evaluate the anti-glycation ability and neuroprotective effect of 4- hydroxybenzaldehyde (4-HBA), 3-hydroxybenzaldehyde (3-HBA), and 2,5-dihydroxyphenylacetic acid (homogentisic acid; HGA) isolated from Sargassum nipponicum. The results confirmed that 4-HBA, 3-HBA, and HGA effectively inhibit the production of AGEs, prevent AGEs-collagen cross-link formation, and cleave pre-formed cross-links between AGEs and collagen, thereby exhibiting anti-glycation properties. Treatment with methylglyoxal (MGO) resulted in increased neuronal PC-12 cell death, intracellular reactive oxygen species production, and intracellular accumulation of MGO and AGEs. However, pretreatment with 4-HBA, 3-HBA, and HGA reduced AGEs production by suppressing MGO accumulation in neuronal PC-12 cells, which consequently lowered intracellular oxidative stress levels and exerted a neuroprotective effect. Notably, HGA exhibited a stronger binding affinity to the receptor for AGEs (RAGE) protein compared to MG-H1 and competitively inhibited AGEs-RAGE interaction, effectively downregulating RAGE protein expression in neuronal PC-12 cells. These findings highlight the chemical and structural properties of HGA derived from S. nipponicum, which effectively target the main mechanisms involved in AGEs-induced diabetic neuropathy. Therefore, HGA holds significant potential as a natural treatment for inhibiting AGEs formation.
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