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논문 기본 정보

자료유형
학술저널
저자정보
이상훈 (한국식품연구원) 조치홍 (한국식품연구원 기능성소재연구단) 유귀재 (한국식품연구원) 올파드위 (과학기술연합대학원대학교) 정영성 (한국식품연구원)
저널정보
한국키틴키토산학회 Journal of Chitin and Chitosan Journal of Chitin and Chitosan Vol.28 No.2
발행연도
2023.6
수록면
77 - 86 (10page)

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Advanced glycation end-products (AGEs) are compounds naturally produced in the body during the glycation reaction. Excessive AGEs bind to long-lived proteins such as collagen and accumulate in the body, leading to AGEs related diabetic complications. This study aimed to evaluate the anti-glycation ability and neuroprotective effect of 4- hydroxybenzaldehyde (4-HBA), 3-hydroxybenzaldehyde (3-HBA), and 2,5-dihydroxyphenylacetic acid (homogentisic acid; HGA) isolated from Sargassum nipponicum. The results confirmed that 4-HBA, 3-HBA, and HGA effectively inhibit the production of AGEs, prevent AGEs-collagen cross-link formation, and cleave pre-formed cross-links between AGEs and collagen, thereby exhibiting anti-glycation properties. Treatment with methylglyoxal (MGO) resulted in increased neuronal PC-12 cell death, intracellular reactive oxygen species production, and intracellular accumulation of MGO and AGEs. However, pretreatment with 4-HBA, 3-HBA, and HGA reduced AGEs production by suppressing MGO accumulation in neuronal PC-12 cells, which consequently lowered intracellular oxidative stress levels and exerted a neuroprotective effect. Notably, HGA exhibited a stronger binding affinity to the receptor for AGEs (RAGE) protein compared to MG-H1 and competitively inhibited AGEs-RAGE interaction, effectively downregulating RAGE protein expression in neuronal PC-12 cells. These findings highlight the chemical and structural properties of HGA derived from S. nipponicum, which effectively target the main mechanisms involved in AGEs-induced diabetic neuropathy. Therefore, HGA holds significant potential as a natural treatment for inhibiting AGEs formation.

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