Effect of gonadotropin-releasing hormone agonist treatment on near final height in girls with central precocious puberty and early puberty

Yang Eun Hye; Jo Ha Young; Park Su Jeong; Yoo Hye Won; Choi Soo-Han; Kim Hye-Young; Park Kyung Hee; Kim Young Mi; Kwak Min Jung

doi:10.6065/apem.2142250.125

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자료유형: 학술저널

저자정보: Yang Eun Hye (Department of Pediatrics Pusan National University Hospital Pusan National University School of Medicine Busan Korea) Jo Ha Young (Department of Pediatrics Pusan National University Hospital Pusan National University School of Medicine Busan Korea) Park Su Jeong (Department of Pediatrics Pusan National University Hospital Pusan National University School of Medicine Busan Korea) Yoo Hye Won (Department of Pediatrics Pusan National University Hospital Pusan National University School of Medicine Busan Korea) Choi Soo-Han (Department of Pediatrics Pusan National University Hospital Pusan National University School of Medicine Busan Korea) Kim Hye-Young (Department of Pediatrics Pusan National University Hospital Pusan National University School of Medicine Busan Korea) Park Kyung Hee (Department of Pediatrics Pusan National University Hospital Pusan National University School of Medicine Busan Korea) Kim Young Mi (Department of Pediatrics Pusan National University Hospital Pusan National University School of Medicine Busan Korea) Kwak Min Jung (Department of Pediatrics Pusan National University Hospital Pusan National University School of Medicine Busan Korea)

저널정보: 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatric Endocrinology & Metabolism 제28권 제1호

발행연도: 2023.3

수록면: 49 - 53 (5page)

DOI: 10.6065/apem.2142250.125

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Purpose: The aim of this study was to examine whether gonadotropin-releasing hormone (GnRH) agonist treatment is effective in preserving final height in patients with central precocious puberty (CPP) or early puberty (EP).Methods: The medical records of 40 patients with CPP and 206 patients with EP who completed GnRH agonist treatment following diagnosis were analyzed retrospectively. Height and height standard deviation (height SDS) scores based on bone age (BA) were measured and calculated at baseline, after treatment completion, and at final follow-up to compare changes within and between groups. Predicted adult height (PAH) was estimated by the height corresponding to height SDS for BA in girls at 18 years 11 months of age based on the growth chart.Results: PAH at baseline did not differ significantly between the CPP group (153.67±4.95) and the EP group (154.77±3.72). In the CPP group, PAH significantly increased at treatment completion (156.01±4.61) and at final follow-up (158.52±6.04) compared to baseline. In the EP group, PAH significantly increased at treatment completion (157.7±3.60) and at final follow-up (159.31±4.26) compared to baseline. The increase in PAH at all timepoints compared to baseline did not significantly differ between the CPP and EP groups.Conclusion: Both CPP and EP groups had significantly greater PAH after treatment, with no difference in the amount of increase between groups. These results show that GnRH agonist treatment can help increase final height even in patients diagnosed with EP after the age of 8 years.

#Precocious puberty #Central precocious puberty #Gonadotropin-releasing hormone agonist

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