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논문 기본 정보

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저자정보
Kang Noeul (Division of Allergy Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.) Won Ha-Kyeong (Department of Internal Medicine Veterans Health Service Medical Center Seoul Korea.) Lee Ji-Hyang (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Medicine Seoul Korea.) Shim Ji-Su (Department of Internal Medicine College of Medicine Ewha Womans University Seoul Korea.) Kang Sung-Yoon (Department of Internal Medicine Gachon University Gil Medical Center Incheon Korea.) 박한기 (Department of Allergy and Clinical Immunology Kyungpook National University Chilgok Hospital School of Medicine Kyungpook National University Daegu Korea.) Jo Eun-Jung (Department of Internal Medicine Pusan National University College of Medicine Busan Korea.) Lee Seung Eun (Department of Internal Medicine Pusan National University Yangsan Hospital Yangsan Korea.) Kim Min-Hye (Department of Internal Medicine College of Medicine Ewha Womans University Seoul Korea.) Kim Sang-Heon (Department of Internal Medicine Hanyang University Hospital Hanyang University College of Medicine Seoul Korea.) Kim Sae-Hoon (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.) 장윤석 (Department of Internal Medicine Seoul National University Bundang Hospital Seoul National University College of Medicine Seongnam Korea.) Lee Byung-Jae (Division of Allergy Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea.) Song Woo-Jung (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Medicine Seoul Korea.) Jo Min-Woo (Department of Preventive Medicine University of Ulsan College of Medicine Seoul Korea.)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.15 No.3
발행연도
2023.5
수록면
348 - 360 (13page)
DOI
10.4168/aair.2023.15.3.348

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Purpose: Chronic cough (CC) is associated with health-related quality of life (HRQoL) impairment. However, the determinants of HRQoL are under-investigated. Methods: Patients aged 19–80 years with CC were prospectively recruited from 10 referral clinics. Comparisons were made with age- and sex-matched controls (1:4 ratio) selected from a Korean general population survey database; 1) a group without current cough (non-cough controls) and 2) another group without major chronic illnesses (healthy controls). HRQoL was assessed using the EuroQoL 5-dimension (EQ-5D) index. In CC patients, cough-specific patient-reported outcomes (PROs) were additionally measured. Cross-sectional analyses were performed to evaluate demographic and clinical parameters associated with the EQ-5D index of CC patients. Results: A total of 200 CC patients (137 newly referred with CC and 63 refractory or unexplained CC [RUCC] patients), 800 non-cough controls, and 799 healthy controls were analyzed. The EQ-5D index of CC patients was significantly lower than that of non-cough controls or healthy controls (0.82 ± 0.14 vs 0.92 ± 0.14/0.96 ± 0.08; P < 0.001, respectively). The index was also associated with older age (≥ 60 years), female sex, and comorbidities such as asthma or depression. Among the patients with CC, the index was significantly lower in patients with RUCC than in those with newly referred CC, being treated with codeine or cough neuromodulators, or with cough-related fatigue. In Spearman analyses, the EQ-5D index correlated with cough-specific quality of life and cough severity scores, not with throat sensation or cough trigger scores. Conclusions: The HRQoL impairment of CC patients was associated with older age, female sex, and comorbidities but it was also affected by cough severity, complications, treatments, and treatment responses. Longitudinal studies are warranted to further understand and improve the HRQoL of CC patients.
#cough #quality of life #health status #cost of illness #registries INTRODUCTION

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