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논문 기본 정보

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학술저널
저자정보
김성국 (농촌진흥청) 문시원 (농촌진흥청) 이문선 (농촌진흥청) 김효영 (농촌진흥청) 최홍민 (농촌진흥청) 김선미 (농촌진흥청) 우순옥 (농촌진흥청)
저널정보
한국양봉학회 Journal of Apiculture Journal of Apiculture Vol.39 No.1
발행연도
2024.4
수록면
73 - 81 (9page)
DOI
10.17519/apiculture.2024.04.39.1.73

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Among the various signal transduction processes in cells against cancer, the activated Wnt signal is activated through the initiation of an intracellular “disheveled” signal, and it is induced cancer through overexpression of intracellular TCF/LEF genes through GSK-3β and binding inhibition of β-catenin. GSK-3β and β-catenin were overexpressed which correspond to Wnt signaling pathway in PANC-1 cells as a pancreatic cancer cells. We prepared a mixed formulation called “honeypolis” that honey and propolis mixture. Through inhibition of PCNA expression and Akt phosphorylation, and increasing of ERK phosphorylation, honeypolis inhibited PANC-1 cell proliferation. However, honeypolis dose not exhibit apoptosis of PANC-1. This effect is caused by specific functional components in propolis and it was confirmed according to the mixing and filtering order of the honeypolis. Cytotoxicity evaluation showed that specific components had an effect on cell death, Western blotting confirmed that the reducing expression of GSK-3β, β-catenin and mTOR protein corresponding to activated Wnt signaling pathway in PANC-1. In addition, this effect has been shown to be enhanced by a mixture of honey and propolis more than honey and propolis only. This result means that honey and propolis mixture has synergistic effects and it can be regulates Wnt signal cascade on PANC-1. Therefore, we suggested that the honeybee products regulates cell functionality about molecular level and it can be used to possibility against cancer.

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