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논문 기본 정보

자료유형
학술저널
저자정보
Jeong So-Jeong (College of Pharmacy, Chungbuk National University) Song Woo Yul (College of Pharmacy, Chungbuk National University) 박천웅 (충북대학교) 김동욱 (원광대학교)
저널정보
한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation Vol.54 No.2
발행연도
2024.3
수록면
131 - 144 (14page)
DOI
10.1007/s40005-023-00656-5

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Background Lymphatic oral drug delivery systems are considered optimal for enhancing oral drug delivery. They offer the advantage of delivering drugs directly to the immune system while bypassing first-pass metabolism. Consequently, they are actively researched in the field of pharmaceuticals. Novel drug delivery systems are employed to administer drugs through the lymphatic system via the oral route. Area covered This review delves into the current understanding of drug delivery systems through the lymphatic pathway, with a focus on those utilizing long-chain triglycerides. We explore the mechanisms of delivery to the lymphatic pathway, characteristics of drugs used for this purpose, composition of lipid-based formulations, preparation methods, evaluation methods, and notable case studies. Expert opinion With the discovery of more lipophilic drug candidates, there is a growing interest in designing formulations to maximize lymphatic transport. Stimulating intestinal lymphatic transport holds the potential for benefits such as reducing first-pass metabolism and delivering high drug concentrations to the lymphatic system. To enhance the utility of intestinal lymph as an alternative means of transport to the systemic circulation, further research is essential. This research should address the underlying mechanisms of drug binding to lipoproteins in intestinal cells, as well as the effects of lipids and formulation excipients on this process.

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