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논문 기본 정보

자료유형
학술저널
저자정보
Bagi Mahsa (Department of Chemical Engineering , Amirkabir University of Technology) Amjad Fatemeh (Department of Biomedical Engineering , Amirkabir University of Technology) Ghoreishian Seyed Majid (Department of Chemical Engineering , University of South Carolina) Sohrabi Shahsavari Somayeh (Department of Chemical Engineering , Amirkabir University of Technology) 허윤석 (인하대학교) Moraveji Mostafa Keshavarz (Department of Chemical Engineering , Amirkabir University of Technology) Shimpalee Sirivatch (Department of Biomedical Engineering , Amirkabir University of Technology)
저널정보
한국바이오칩학회 BioChip Journal BioChip Journal Vol.18 No.1
발행연도
2024.3
수록면
45 - 67 (23page)
DOI
10.1007/s13206-023-00131-1

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Separation of micro- and nano-sized bioparticles is essential for efficient diagnostics, chemical and biological analyses, drug development, food and chemical processing, and environmental monitoring. However, most of the currently available bio- separation techniques are based on the membrane filtration approach, whose efficiency is restricted by membrane-related disadvantages, including pore size, surface charge density, and biocompatibility, which results in a reduction in the isolation resolution. To address these issues, till now, many microfluidic devices have been developed for particle/cell profi ling due to their excellent sensitivity and specificity, less sample consumption, shortened processing time, and high throughput features. Of the various microfluidic systems, the spiral inertial microfluidic technique has recently attracted attention as an innovative strategy and advanced cutting-edge technology toward bioparticle separation. Depending on the needs of the microfluidic device, the spiral inertial chip can be customized to separate bioparticles owing to their sizes and different shapes. In this review, we discuss the kinematics of microchannel particle separation mechanisms, recent developments in the inertial microfluidic device realm, and their applications for the separation of several types of bioparticles, including blood cells, stem cells, sperm cells, pathogens, and algae. Finally, we highlight challenges and economical perspectives associated with guidelines for further development of spiral inertial microfluidic devices in the future.

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