지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 85 - 92 (8page)
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초록· 키워드
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Importance: Carbapenem-resistant Enterobacteriaceae are emerging as a global public health risk. Therefore, assessing the prevalence of carbapenem-resistant Escherichia coli (CRE) in both humans and animals is important.
Objective: We aimed to ascertain the occurrence and characteristics of CRE isolated from companion animals, dogs and cats.
Methods: E. coli strains were tested for antimicrobial susceptibility using the broth microdilution technique. Antimicrobial resistance genes were detected by polymerase chain reaction and sequencing analysis. The molecular characteristics of CRE were determined using multi-locus sequence typing, replicon typing, and pulsed-field gel electrophoresis (PFGE).
Results: In total, 13 CRE isolates (0.13%) were identified from dogs possessing bla<SUB>NDM-5</SUB> along with β-lactamase genes, mostly bla<SUB>CMY-2</SUB> (92.2%) and bla<SUB>TEM-1</SUB> (53.8%). The commonly observed mutations were S83L and D87N in gyrA, S80I in parC, and S458A in parE. CRE carried nonbeta-lactam resistance genes, with the majority being tet(B) (100%), sul (84.6%), and aac(3)-II (53.8%). Nine different PFGE patterns (P1-P9), IncX3-type plasmids (69.2%), and ST410 (84.6%) were predominantly detected.
Conclusions and Relevance: This investigation provides significant insight into the prevalence and molecular characteristics of bla<SUB>NDM-5</SUB>-carrying E. coli in dogs. The co-existence of bla<SUB>NDM-5</SUB> and other antimicrobial resistance genes in E. coli potentially poses severe health hazards to humans.
Objective: We aimed to ascertain the occurrence and characteristics of CRE isolated from companion animals, dogs and cats.
Methods: E. coli strains were tested for antimicrobial susceptibility using the broth microdilution technique. Antimicrobial resistance genes were detected by polymerase chain reaction and sequencing analysis. The molecular characteristics of CRE were determined using multi-locus sequence typing, replicon typing, and pulsed-field gel electrophoresis (PFGE).
Results: In total, 13 CRE isolates (0.13%) were identified from dogs possessing bla<SUB>NDM-5</SUB> along with β-lactamase genes, mostly bla<SUB>CMY-2</SUB> (92.2%) and bla<SUB>TEM-1</SUB> (53.8%). The commonly observed mutations were S83L and D87N in gyrA, S80I in parC, and S458A in parE. CRE carried nonbeta-lactam resistance genes, with the majority being tet(B) (100%), sul (84.6%), and aac(3)-II (53.8%). Nine different PFGE patterns (P1-P9), IncX3-type plasmids (69.2%), and ST410 (84.6%) were predominantly detected.
Conclusions and Relevance: This investigation provides significant insight into the prevalence and molecular characteristics of bla<SUB>NDM-5</SUB>-carrying E. coli in dogs. The co-existence of bla<SUB>NDM-5</SUB> and other antimicrobial resistance genes in E. coli potentially poses severe health hazards to humans.
목차
ABSTRACT
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
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