지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.10
- 수록면
- 441 - 455 (15page)
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초록· 키워드
오류제보하기
This study objective was to evaluate the effects and mechanisms of low-level laser therapy in H₂O₂-induced cell death in mouse macrophage RAW264.7 cell. After irradiation with 630 and 850 nm wavelength diode lasers with an intensity of 10 mW/cm² in RAW264.7 cells treated with 0.7 Mm H₂O₂, the effects and mechanisms of the two wavelengths on cell death inhibition were evaluated using MTT assay, ROS staining, TUNEL assay, flow cytometry analysis, and Western blot analysis. As a result, 630 or 850 nm light-emitting diodes (LED) were irradiated for 10 or 40 minutes to increase cell viability with H₂O₂ by about 1.7- or 1.6-fold, respectively. In addition, irradiation with two LEDs showed significant ROS scavenging effects, and TUNEL-positive cells were significantly reduced by 45.7% (630 nm) and 37.8% (850 nm) compared to cells treated with H₂O₂ alone. The Bax/Bcl-2 ratio of cells irradiated with both LEDs was significantly lower than that of cells treated with H₂O₂ only, and the expression of pro-caspase-3 and cleaved PARP was also significantly expressed in the direction of suppressing cell death. In conclusion, ROS scavenging activity by both LEDs irradiation leads to the expression of cell death pathway proteins in the direction of inhibiting cell death.
목차
I. INTRODUCTION
II. METHOD
III. RESULTS
IV. DISCUSSION
V. CONCLUSION
REFERENCES
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