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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.9
- 수록면
- 213 - 224 (12page)
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초록· 키워드
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Streptococcus pneumoniae (S. pneumoniae, Pneumococcus) is a predominant pathogen in community-acquired pneumonia. Infection animal models using certain pneumococcal serotypes are well established, but some serotypes, such as ST14 and ST23F, exhibit low or negligible infectivity in mouse models, posing challenges for the development of comprehensive pneumococcal vaccines. In this study, we developed human lung organoids (hLOs) derived from human embryonic stem cells (hESCs) to model pneumococcal infection. hLOs were microinjected with serotype ST23F to assess its infective potential compared with ST4. Our results demonstrate that ST23F successfully colonizes and invades the epithelial cells of hLOs, triggering significant inflammatory responses. This response was quantitatively comparable to that induced by the highly virulent serotype ST4 in mouse models. This organoid-based infection model provides a viable and effective platform for studying pneumococcal serotypes that are inadequately represented in traditional mouse models. Furthermore, it underscores the potential utility of hLOs in the preclinical evaluation of novel multivalent pneumococcal conjugate vaccines, addressing serotypes with historically low virulence in animal models
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
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