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논문 기본 정보

자료유형
학술저널
저자정보
Huang Hao (Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao 266003, P.R. ChinaSchool of Stomatology, Qingdao University, Qingdao 266023, P.R. China) Han Rui (Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao 266003, P.R. ChinaSchool of Stomatology, Qingdao University, Qingdao 266023, P.R. China) Huang Ping-Ping (Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao 266003, P.R. ChinaSchool of Stomatology, Qingdao University, Qingdao 266023, P.R. China) Qiao Chuan-Yue (Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao 266003, P.R. ChinaSchool of Stomatology, Qingdao University, Qingdao 266023, P.R. China) Bian Shuang (Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao 266003, P.R. ChinaSchool of Stomatology, Qingdao University, Qingdao 266023, P.R. China) Xiao Han (Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao 266003, P.R. ChinaSchool of Stomatology, Qingdao University, Qingdao 266023, P.R. China) Ma Lei (Department of Prosthodontics, The Affiliated Hospital of Qingdao University, Qingdao 266003, P.R. ChinaSchool of Stomatology, Qingdao University, Qingdao 266023, P.R. China)
저널정보
한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology Vol.34 No.6
발행연도
2024.6
수록면
1,229 - 1,238 (10page)
DOI
10.4014/jmb.2402.02055

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초록· 키워드

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This study aimed to develop and assess a chitosan biomedical antibacterial gel ZincOxideGrapheneOxide/Chitosan/β-Glycerophosphate (ZnO-GO/CS/β-GP) loaded with nano-zinc oxide (ZnO) and graphene oxide (GO), known for its potent antibacterial properties, biocompatibility, and sustained drug release. ZnO nanoparticles (ZnO-NPs) were modified and integrated with GO sheets to create 1% and 3% ZnO-GO/CS/β-GP thermo-sensitive hydrogels based on ZnO-GO to Chitosan (CS) mass ratio. Gelation time, pH, structural changes, and microscopic morphology were evaluated. The hydrogel's antibacterial efficacy against Porphyromonas gingivalis, biofilm biomass, and metabolic activity was examined alongside its impact (MC3T3-e1). The findings of this study revealed that both hydrogel formulations exhibited temperature sensitivity, maintaining a neutral pH. The ZnO-GO/CS/β-GP formulation effectively inhibited P. gingivalis bacterial activity and biofilm formation, with a 3% ZnO-GO/CS/β-GP antibacterial rate approaching 100%. MC3T3-e1 cells displayed good biocompatibility when cultured in the hydrogel extract.The ZnO-GO/CS/β-GP thermo-sensitive hydrogel demonstrates favorable physical and chemical properties, effectively preventing P. gingivalis biofilm formation. It exhibits promising biocompatibility, suggesting its potential as an adjuvant therapy for managing and preventing peri-implantitis, subject to further clinical investigations.

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