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논문 기본 정보

자료유형
학술저널
저자정보
손경모 (인제대학교 해운대백병원)
저널정보
대한임상신경생리학회 Annals of Clinical Neurophysiology Annals of Clinical Neurophysiology Vol.26 No.1
발행연도
2024.4
수록면
14 - 21 (8page)
DOI
https://doi.org/10.14253/acn.23013

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Background: This study aimed to determine the characteristics of computed tomography perfusion (CTP) patterns and their utility in predicting antiseizure medication (ASM) resistance in patients with nonconvulsive status epilepticus (NCSE). Methods: We retrospectively reviewed patients diagnosed with NCSE at Inje University Hae undae Paik Hospital Epilepsy Center between March 2015 and March 2022. CTP patterns were analyzed for those patients. A hyperperfusion pattern (HPP) in CTP was defined as a region of both increased cerebral blood flow and cerebral blood volume that did not necessarily follow the vascular territories. The primary endpoint was the responses to ASMs according to CTP patterns. Results: Fourteen (74%) of the 19 included patients met the criteria for definite NCSE, with the remaining 26% showing nonepileptiform activities with fluctuating quasirhythmic delta activities at >0.5 Hz on electroencephalogram. Three of the four patients who had HPPs with thalamic involvement were refractory to ASMs, whereas all eight patients who had HPPs with out thalamic involvement were responsive to ASMs (p = 0.018). Although HPPs themselves were not associated with ASM responses, HPPs with thalamic involvement were associated with resistance to ASMs. Conclusions: HPP with thalamic involvement in CTP might be associated with ASM resis tance. Therefore, CTP may be useful for predicting ASM resistance in NCSE patients

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