지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.11
- 수록면
- 451 - 457 (7page)
이용수
초록· 키워드
오류제보하기
Backgrounds/Aims: A postoperative biliary leak is one of the most morbid complications occurring after a liver resection, the long-term impact of which remains unknown.
Methods: Retrospective analysis of consecutive liver resections performed from 1 January 2011 to 31 December 2021. Primary endpoint of disease-free survival (DFS) was compared between patients with and without a bile leak, stratifying for tumor type. Survival curves were plotted using Kaplan–Meier estimates, and differences between them were analyzed using the log–rank test.
Results: In toto, 862 patients were analyzed, and included 306 (35.5%) hepatocellular carcinomas, 212 (24.6%) metastatic colorectal cancers, and 111 (12.9%) cholangiocarcinomas (69 intrahepatic cholangiocarcinomas, 42 hilar cholangiocarcinomas). Occurrence of a bile leak was associated with significantly poorer DFS only in patients with cholangiocarcinoma (median DFS 9.9 months vs. 24.9 months, p = 0.013), and further analysis was restricted to this cohort. A Cox regression performed for factors associated with DFS detriment in patients with cholangiocarcinoma showed that apart from node positivity (hazard ratio [HR]: 2.482, p = 0.033) and margin positivity (HR: 2.65, p = 0.021), development of a bile leak was independently associated with worsening DFS on both univariate and multiple regression analyses (HR: 1.896, p = 0.033).
Conclusions: Post-hepatectomy biliary leaks are associated with significantly poorer DFS only in patients with cholangiocarcinoma, but not in patients with hepatocellular carcinoma or metastatic colorectal cancer. Methods to mitigate this survival detriment need to be explored.
Methods: Retrospective analysis of consecutive liver resections performed from 1 January 2011 to 31 December 2021. Primary endpoint of disease-free survival (DFS) was compared between patients with and without a bile leak, stratifying for tumor type. Survival curves were plotted using Kaplan–Meier estimates, and differences between them were analyzed using the log–rank test.
Results: In toto, 862 patients were analyzed, and included 306 (35.5%) hepatocellular carcinomas, 212 (24.6%) metastatic colorectal cancers, and 111 (12.9%) cholangiocarcinomas (69 intrahepatic cholangiocarcinomas, 42 hilar cholangiocarcinomas). Occurrence of a bile leak was associated with significantly poorer DFS only in patients with cholangiocarcinoma (median DFS 9.9 months vs. 24.9 months, p = 0.013), and further analysis was restricted to this cohort. A Cox regression performed for factors associated with DFS detriment in patients with cholangiocarcinoma showed that apart from node positivity (hazard ratio [HR]: 2.482, p = 0.033) and margin positivity (HR: 2.65, p = 0.021), development of a bile leak was independently associated with worsening DFS on both univariate and multiple regression analyses (HR: 1.896, p = 0.033).
Conclusions: Post-hepatectomy biliary leaks are associated with significantly poorer DFS only in patients with cholangiocarcinoma, but not in patients with hepatocellular carcinoma or metastatic colorectal cancer. Methods to mitigate this survival detriment need to be explored.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Comparison of clinical results of surgical resection for extrahepatic cholangiocarcinomas : hilar cholangiocarcinoma and mid to distal cholangiocarcinoma.
대한외과학회 학술대회 초록집
2017 .11
-
간내 담관암: 최신 개념 및 내과적 치료
대한췌담도학회지
2021 .01
-
Intrahepatic Cholangiocarcinoma
대한외과학회 학술대회 초록집
2021 .11
-
Five Year Survival of Combined Hepatocellular and Cholangiocarcinoma Compared with Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma : IPTW Analysis
대한외과학회 학술대회 초록집
2022 .11
-
Comparison of Clinical Characteristics between Occupational and Sporadic Young-Onset Cholangiocarcinoma
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Mandibular metastasis of cholangiocarcinoma: A case report
Imaging science in dentistry
2015 .01
-
Effect of age on the prognosis of intrahepatic cholangiocarcinoma
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .12
-
Chronological analysis of surgical and oncological outcomes after the treatment of perihilar cholangiocarcinoma
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .02
-
Outcome of surgical treatment of hilar cholangiocarcinoma in a single center
대한외과학회 학술대회 초록집
2017 .11
-
Genetic features associated with 18F-FDG uptake in intrahepatic cholangiocarcinoma
Annals of Surgical Treatment and Research
2019 .04
-
Liver transplantation for combined hepatocellular carcinoma and cholangiocarcinoma in Korea
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .12
-
Laparoscopic resection of hilar cholangiocarcinoma
Annals of Surgical Treatment and Research
2015 .09
-
Laparoscopic Liver Resection for Cholangiocarcinoma
대한외과학회 학술대회 초록집
2017 .11
-
Comprehensive management of cholangiocarcinoma: Part I. Diagnosis
International Journal of Gastrointestinal Intervention
2017 .07
-
The Feasibility and Outcome of Patients Undergoing Liver Transplantation for Combined Hepatocellular-cholangiocarcinoma
대한외과학회 학술대회 초록집
2022 .11
-
The feasibility and outcome of patients undergoing liver transplantation for combined hepatocellular-cholangiocarcinoma
Annals of Hepato-Biliary-Pancreatic Surgery
2022 .12
-
Comparison of oncologic outcomes of extrahepatic cholangiocarcinoma according to tumor location: perihilar cholangiocarcinoma versus distal bile duct cancer
Annals of Surgical Treatment and Research
2022 .02
-
Necrosectomy of hepatic left lateral section after blunt abdominal trauma in a patient who underwent central hepatectomy and bile duct resection for perihilar cholangiocarcinoma
Annals of Hepato-Biliary-Pancreatic Surgery
2020 .08
-
Post-resection prognosis of combined hepatocellular carcinoma-cholangiocarcinoma according to the 2019 WHO classification
Annals of Hepato-Biliary-Pancreatic Surgery
2021 .12
-
Post-resection prognosis of combined hepatocellular carcinoma-cholangiocarcinoma according to the 2010 WHO classification
한국간담췌외과학회 학술대회지
2016 .04
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-151-25-02-091049650