메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류

추천
검색
질문

논문 기본 정보

자료유형
학술저널
저자정보
Wenjun Xu (Zhejiang Normal University) Ziling Yang (Beijing University of Chinese Medicine) Hanyang Wu (Zhejiang Normal University) Yanjing Le (Xi’an Jiaotong University) Xueling Yao (Xi’an Jiaotong University) Shiju E (Zhejiang Normal University)
저널정보
한국전자파학회JEES Journal of Electromagnetic Engineering And Science Journal of Electromagnetic Engineering And Science Vol.24 No.6
발행연도
2024.11
수록면
620 - 631 (12page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색
질문

초록· 키워드

오류제보하기
Pulsed electromagnetic field (PMF) treatment based on the dielectric difference between cancer cells and normal cells is a recently discovered novel cancer treatment. However, the mechanism behind PMF irradiation of cancer cells is not clear, and the relationship between the biological effect of cancer cells and PMF irradiation parameters is difficult to predict, leading to difficulties in its application in cancer therapy. In this paper, we designed nanosecond and microsecond PMFs for rat glioma cells (C6) considering different parameters— frequency, rise rate dB/dt, intensity B, action integral ΣBΔt, and energy action integral ΣB2Δt—to accurately describe PMFs. The results point to a statistically significant window effect and cumulative effect of PMFs on cancer cell viability. In particular, the results of nanosecond PMFs showed that low-frequency and low-intensity electromagnetic fields are more likely to inhibit the proliferation of C6 cells. At a frequency of 1 Hz, C6 cell viability was inhibited by about 10%–15%. Furthermore, when the intensity was 0.353 mT, nanosecond PMFs showed an inhibitory effect, except at 10 Hz. The effective inhibition values of the magnetic field parameters dB/dt (T/s), Bt (mT·s), and B2t (mT ² ·s) after microsecond PMFs were [4.14 × 10³ , 5.65 × 10 ⁴ ], [1.18 × 10<sup>-2</sup> , 4.51 × 10 <sup>-2</sup> ], and [1.28, 11.30], respectively. It is noted that the rise rate (dB/dt) of PMFs plays a major role in inhibiting cancer cell proliferation. Furthermore, when the difference of dB/dt is small, the intensity becomes the main factor affecting cancer cell viability. Overall, this study establishes theoretical and experimental foundations for the study of electromagnetic biological effects and their clinical applications.

목차

Abstract
I. INTRODUCTION
II. MATERIALS AND METHODS
III. RESULTS
IV. DISCUSSION
V. CONCLUSION
REFERENCES

참고문헌 (0)

참고문헌 신청

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

최근 본 자료

전체보기

댓글(0)

0

UCI(KEPA) : I410-151-25-02-091184850