지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2024.12
- 수록면
- 393 - 401 (9page)
- DOI
- 10.7783/KJMCS.2024.32.6.393
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초록· 키워드
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Back ground: Inflammatory bowel disease (IBD) is a pathological condition of the gastrointestinal tract characterized by chronic and relapsing inflammation. This study investigated the anti-inflammatory effects of Pyrus calleryana var. fauriei extract (PCE) in vitro and in vivo.
Methods and Results: Lipopolysaccharide (LPS)-treated RAW 264.7 cells and dextran sulfate sodium (DSS)-induced colitis mice were used to evaluate the effects of PCE. In RAW 264.7 cells, PCE inhibited nitric oxide production and phagocytosis without cytotoxicity, and the production of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin (IL)-6. Colitis was induced in the mice using 2% DSS for 5 days, and PCE was administered for 14 days. PCE treatment relieved the symptoms of colitis, such as weight loss, diarrhea, and bloody feces. Moreover, PCE ameliorated splenomegaly and colonic shortening, indicators of colitis. PCE reduced the levels of inflammatory cytokines, IL-6 and IL-22. Histological analysis revealed that PCE treatment alleviated colonic mucosal damage and macrophage infiltration.
Conclusions: These results suggest that PCE has anti-inflammatory activity on LPS-treated RAW 264.7 cells, and ameliorates the clinical symptoms and colonic mucosal damage of DSS-induced colitis in mice. Therefore, PCE is a potential therapeutic candidate for the treatment of IBD.
Methods and Results: Lipopolysaccharide (LPS)-treated RAW 264.7 cells and dextran sulfate sodium (DSS)-induced colitis mice were used to evaluate the effects of PCE. In RAW 264.7 cells, PCE inhibited nitric oxide production and phagocytosis without cytotoxicity, and the production of the pro-inflammatory cytokines tumor necrosis factor-α and interleukin (IL)-6. Colitis was induced in the mice using 2% DSS for 5 days, and PCE was administered for 14 days. PCE treatment relieved the symptoms of colitis, such as weight loss, diarrhea, and bloody feces. Moreover, PCE ameliorated splenomegaly and colonic shortening, indicators of colitis. PCE reduced the levels of inflammatory cytokines, IL-6 and IL-22. Histological analysis revealed that PCE treatment alleviated colonic mucosal damage and macrophage infiltration.
Conclusions: These results suggest that PCE has anti-inflammatory activity on LPS-treated RAW 264.7 cells, and ameliorates the clinical symptoms and colonic mucosal damage of DSS-induced colitis in mice. Therefore, PCE is a potential therapeutic candidate for the treatment of IBD.
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