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논문 기본 정보

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학술저널
저자정보
Thangam T. (Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology) Parthasarathy Krupakar (Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology) Supraja K. (Medway Hospitals, India) Haribalaji V. (VivagenDx, India) Sounderrajan Vignesh (Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology) Rao Sudhanarayani S. (Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology) Jayaraj Sakthivel (Centre for Drug Discovery and Development, Sathyabama Institute of Science and Technology)
저널정보
한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제21권 제5호
발행연도
2024.7
수록면
653 - 671 (19page)
DOI
10.1007/s13770-024-00628-2

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Organoids are essentially an in vitro (lab-grown) three-dimensional tissue culture system model that meticulously replicates the structure and physiology of human organs. A few of the present applications of organoids are in the basic biological research area, molecular medicine and pharmaceutical drug testing. Organoids are crucial in connecting the gap between animal models and human clinical trials during the drug discovery process, which significantly lowers the time duration and cost associated with each stage of testing. Likewise, they can be used to understand cell-to-cell interactions, a crucial aspect of tissue biology and regeneration, and to model disease pathogenesis at various stages of the disease. Lung organoids can be utilized to explore numerous pathophysiological activities of a lung since they share similarities with its function. Researchers have been trying to recreate the complex nature of the lung by developing various “Lung organoids” models. This article is a systematic review of various developments of lung organoids and their potential progenitors. It also covers the in-depth applications of lung organoids for the advancement of translational research. The review discusses the methodologies to establish different types of lung organoids for studying the regenerative capability of the respiratory system and comprehending various respiratory diseases. Respiratory diseases are among the most common worldwide, and the growing burden must be addressed instantaneously. Lung organoids along with diverse bio-engineering tools and technologies will serve as a novel model for studying the pathophysiology of various respiratory diseases and for drug screening purposes.

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