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논문 기본 정보

자료유형
학술저널
저자정보
Amna Touseef (Department of Biology, Faculty of Science, Al-Baha University) Shamshi Hassan M. (Department of Chemistry, Faculty of Science, Al-Baha University) Algethami Jari S. (Department of Chemistry, College of Science and Arts, Najran University) Aljuaid Alya (Department of Biology, College of Science and Humanities, Shaqra University) Alfarsi Anas (Department of Chemistry, Faculty of Science, Al-Baha University) Alnefaie Rasha (Department of Biology, Faculty of Science, Al-Baha University) Sheikh Faheem A. (Department of Nanotechnology, University of Kashmir) Khil Myung-Seob (Department of Organic Materials and Textile Engineering, Jeonbuk National University)
저널정보
한국조직공학과 재생의학회 조직공학과 재생의학 조직공학과 재생의학 제21권 제5호
발행연도
2024.7
수록면
711 - 721 (11page)
DOI
10.1007/s13770-024-00630-8

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BACKGROUND: In this study an approach was made to efficaciously synthesize gold enhanced titania nanorods by electrospinning. This study aims to address effects of gold enhanced titania nanorods on muscle precursor cells. Additionally, implant related microbial infections are prime cause of various disastrous diseases. So, there is predictable demand for synthesis of novel materials with multifunctional adaptability. METHODS: Herein, gold nanoparticles were attached on titania nanorods and described using many sophisticated procedures such as XRD, SEM, EDX and TEM. Antimicrobial studies were probed against Gram-negative Escherichia coli. C2C12 cell lines were exposed to various doses of as-prepared gold enhanced titania nanorods in order to test in vitro cytotoxicity and proliferation. Cell sustainability was assessed through Cell Counting Kit–8 assay at regular intervals. A phase-contrast microscope was used to examine morphology of exposed C2C12 cells and confocal laser scanning microscope was used to quantify cell viability. RESULTS: The findings indicate that titania nanorods enhanced with gold exhibit superior antimicrobial efficacy compared to pure titania. Furthermore, newly synthesized gold-enhanced titania nanorods illustrate that cell viability follows a time and concentration dependent pattern. CONCLUSION: Consequently, our study provides optimistic findings indicating that titania nanorods adorned with gold hold significant potential as foundational resource for developing forthcoming antimicrobial materials, suitable for applications both in medical and biomedical fields. This work also demonstrates that in addition to being extremely biocompatible, titania nanorods with gold embellishments may be used in a range of tissue engineering applications in very near future.

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